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Медицинская химия и разработка лекарств

Academic Press, 2013. — 160 p. The purpose of this book is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables'...
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Sixth Edition. - Wiley-Interscience, A John Wiley and Sons, Inc., Puplication. - 2003. - 946 p. Язык: английский. Книга состоит из 20 глав и содержит исчерпывающую информацию о современных тенденциях синтеза новых фармацевтических субстанций и развития новых лекарственных форм, проанализирована взаимосвязь структуры соедининия с его фармакологическим действием на биомишень,...
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Sixth Edition. - A Wiley-Interscience Puplication, A John Wiley and Sons, Inc., . - 2003. - 817 p. Язык: английский. В книге, состоящей из 20 глав, изложены основные принципы комбинаторной химии, используемые в медицинской химии и при разработке новых лекарств, методы скрининга потенциальных терапевтических агентов, основные фармакодинамические и фармакокинетические показатели,...
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Sixth Edition. - Wiley-Interscience, A John Wiley and Sons, Inc., Puplication. - 2003. - 885 p. Язык: английский. Книга состоит из 15 глав и содержит исчерпывающую информацию о лекарственных средствах, действующих (напрямую или опосредованно) на сердечно-сосудистую систему, а также о гормональных препаратах. Рекомендована для студентов, аспирантов и специалистов области...
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Sixth Edition. - Wiley-Interscience, A John Wiley and Sons, Inc., Puplication. - 2003. - 716 p. Язык: английский. Книга состоит из 13 глав и содержит исчерпывающую информацию о современных пептидных и нуклеотидных препаратах, витаминах, а также рентгеноконтрастных веществах. Рекомендована для студентов, аспирантов и специалистов области "Фармация".
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Sixth Edition. - Wiley-Interscience, A John Wiley and Sons, Inc., Puplication. - 2003. - 1127 p. Язык: английский. Книга состоит из 20 глав и содержит исчерпывающую информацию о современных хемотерапектических и антибактериальных лекарственных средствах разных фармакологических групп. Рекомендована для студентов, аспирантов и специалистов области "Фармация".
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Sixth Edition. - Wiley-Interscience, A John Wiley and Sons, Inc., Puplication. - 2003. - 1080 p. Язык: английский. Книга состоит из 15 глав и содержит исчерпывающую информацию о современных лекарственных средствах, действующих преимущественно на центральную и периферицескую нервную систему. Рекомендована для студентов, аспирантов и специалистов области "Фармация".
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Wiley, 2016. — 439 p. This book is the first to combine computational material science and modeling of molecular solid states for pharmaceutical industry applications. Provides descriptive and applied state–of–the–art computational approaches and workflows to guide pharmaceutical solid state chemistry experiments and to support/troubleshoot API solid state selection;...
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Elsevier, 2006. — 437 p. — ISBN 13:978-0-12-088561-9; ISBN 10:0-12-088561-1. Strategies for Drug Discovery A Survey of Novel Molecular Targets for Anticancer Drug Discovery John K. Buolamwini Introduction Overview of Growth Factor Induced Mitogenic Signaling Protein Kinases and Phosphatases Adapter Proteins GTP-Binding Proteins Oncogenic Transcription Factors Apoptosis, Cell...
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Elsevier, 2010. — 621 p. — ISBN 978—81——312—2189—1. Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal...
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Elsevier, 2010. — 547 p. — ISBN 978—81—312—2190—7. Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal...
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The Royal Society of Chemistry, 1998. - 338 p. Since Pasteur in 1846, scientists have been aware that many drugs are photoreactive, but until recently research in this area had been somewhat limited. However, since the introduction of acutely sensitive analytical methods, the realisation of the need to identify the photochemical properties of a potential drug as early in its...
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Publisher: Wiley-VCH. 1996. 736 pages. Language: English This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum,...
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Academic Press, 2018. — 338 p. — ISBN 978-0-12-809217-0. This book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid...
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Taylor & Francis, 2005. - 451 p. Contents Part 1 Perspectives on Virtual Screening Virtual Screening: Scope and Limitations Addressing the Virtual Screening Challenge: The Flex* Approach An Analysis of Critical Factors Affecting Docking and Scoring Part II Compound and Hit Suitability for Virtual Screening Compound Selection for Virtual Screening Experimental...
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Kluwer Academic Publishers, 2002. — 555 p. Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
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Springer Berlin Heidelberg New York, Springer-Verlag Berlin Heidelberg 2007. — 457 p. — ISSN 1862-2461, ISBN-10 3-540-33119-0, ISBN-13 978-3-540-33119-3. Contents . Anti-hormone Therapy: Principles of Endocrine Therapy of Cancer. Inhibition of Growth Factor Signaling by Small-Molecule Inhibitors of ErbB, Raf, and MEK. Farnesyl Protein Transferase Inhibitors: Medicinal...
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Wiley, 2012. — 744 p. A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in...
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Springer, 2019. — 220 p. — (Environmental Chemistry for a Sustainable World). — ISBN 10 3030018806, 13 978-3030018801. This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters...
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Springer, 2019. — 290 p. — (Environmental Chemistry for a Sustainable World). — ISBN 10 3030018806, 13 978-3030018801. This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters...
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Bentham Science, 2011. — 283 p. Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and...
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Bentham Science Publishers, 2014. — 295 p. Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to...
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Bentham eBooks, 2014. — 370 p. — ISBN 160805912X. This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput...
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Bentham eBooks, 2017. — 211 p. — ISBN 1681082926. This Book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the eBook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput...
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Wiley, 2004. - 279 p. - The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies,...
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Springer, 2013 — 625 p. This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods,...
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Second Edition. CRC Press, 2005. — 376 р. Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find...
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ISTE Press - Elsevier, 2018. — 162 p. — ISBN 978-1-78548-288-5. This book presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia – the...
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Springer International Publishing AG, 2018. — 88 p. — ISBN 3319732374. Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced...
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Springer International Publishing AG, 2018. — 72 p. — ISBN 3319732374. Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced...
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12th ed. Lippincott Williams & Wilkins, a Wolters Kluwer business. 2011. 1022 p. For over half a century, Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Twelfth Edition, the...
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New York – London: Taylor and Francis Group, 2006, – 757 p. Features. Describing a practical methodology for the routine scale-up of microencapsulation processes, this handbook. covers the latest developments in the production of polymeric micro- and nanoparticles, lipospheres, solid lipid particles, liposomes, amphiphilic cyclodextrin-based nanoparticles, flexible vesicles,...
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Springer Heidelberg New York Dordrecht London, 2014. XXI, 547 p. — ISBN 978-3-642-53979-4, ISBN 978-3-642-53980-0 (eBook), DOI 10.1007/978-3-642-53980-0 — (Springer Series in Biomaterials Science and Engineering 2). Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and...
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Apple Academic Press, 2016. — 379 p. This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a...
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Springer International Publishing, Switzerland, 2016. — 227 p. — ISBN: 9783319407449 This book discusses the various classes of antibiotics and their mechanisms of action. Millions of lives have been saved by antibiotics since they were first discovered about 90 years ago. For the first few decades antibiotics had remarkable success. Encouraged by the remarkable success, in...
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The Royal Society of Chemistry, 2016. — 536 p. — (RSC Drug Discovery Series No. 53) — ISBN 1782627863. Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods...
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Wiley, 2003. - 262 p. - The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is...
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ASM Press, 2007. — 386 p. A vital, comprehensive overview from some of the world’s leading researchers and scholars in this field. Discusses bβ-Lactamases and aminoglycoside-modifying enzymes as well as other enzymatic mechanisms that result in resistance. Covers the different ways bacteria share resistance determinants, both vertically and horizontally. Offers strategies to...
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Статья. Опубликована в журнале Handb Exp Pharmacol. 2010;(199):79-112 Delivery of biologically active agents to animals is often perceived to be the poor relation of human drug delivery. Yet this field has a long and successful history of species-specific device and formulation development, ranging from simple approaches and devices used in production animals to more...
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Wiley-VCH, 2014. — 326 p. — ISBN: 9783527333646 In 1999, Gisbert Schneider coined the term “scaffold hopping” for a systematic approach to modify the molecular skeleton of a lead structure. Whereas in bioisosteric replacement atoms or small groups are substituted by other ones with identical or at least similar stereoelectronic features, scaffold hopping exchanges the central...
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Wiley-VCH, 2012. — 258 p. — ISBN 978-3-527-33015-7. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. Principles Bioisosterism in Medicinal...
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Boca Raton: CRC Press, 2003. — 829 p. Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure...
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WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 2002. 605 pp. This book deals with established analgesics as well as with new chemical entities for established and new targets. Compounds are classified with respect to their physiological target. In every case the structural formula is given as well as further information e.g. on the pharmacological profile, synthetic routes or...
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Wiley, 2017. — 418 p. Presents a detailed discussion of important solid–state properties, methods, and applications of solid–state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X–ray...
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Second Edition. — New York: Humana Press. 2014. — 596 p. Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug...
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The Royal Society of Chemistry, 2018. — 337 p. Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including...
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John Wiley & Sons, 2003. - 288 p. List of contributors Acknowledgments Introduction to Model Systems in Drug Discovery Growing Yeast for Fun and Profit: Use of Saccharomyces cerevisiae as a Model System in Drug Discovery Caenorhabditis elegans Functional Genomics in Drug Discovery: Expanding Paradigms Drosophila as a Tool for Drug Discovery Drosophila – a Model System for...
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Amsterdam: Elsevier, 2017. — 4611 p. Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and...
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Springer Nature, Singapore, Pte Ltd., 2017. — 667 p. — ISBN 9789811061400. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in...
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Springer Nature, Singapore, Pte Ltd., 2017. — 667 p. — ISBN 9789811061400. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in...
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Springer, 2013. — 408 p. This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity,...
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Springer, 2019. — 147 p. — ISBN-10 9811336563. This book summarizes the recent advances in applications of starch in state-of-the-art drug carriers (hydrogel, micro- and nano-particulate carriers) with stimulus-responsive and target-specific properties. It also highlights the role of starch and its derivatives in transmucosal administration to improve the bioavailability of drugs....
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ITexLi, 2016. — 188 p. — ISBN ISBN: 9535128000 9535127993. — Medicine - drug discovery, pharmaceutical Sector. This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. This book will facilitate your efforts in drug discovery. Drug discovery involves multiple disciplines, technologies, and...
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Springer, 2016. — 100 p. This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book...
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John Wiley & Sons, Inc., 2012. — 533 p. This book includes 14 chapters. Chapter 1 presents a historical view on dendrimer chemistry and gives supramolecular perspectives on dendrimers. Chapter 2 focuses on the physicochemical properties of dendrimers and dendrimer complexes. Chapter 3 discusses the use of dendrimers to tailor the physicochemical and therapeutic properties of...
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Wiley, 2006. — 466 p. Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully...
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Cambridge: RSC Pub, 2012. This book documents the latest research into the theory and application of force-fields, semi-empirical molecular orbital, density functional and ab initio calculations, Quantum Mechanical (QM) based modelling, Atoms in Molecules (AIM) approach, and biomolecular dynamics. It also covers theory and application of 2D cheminformatics, QSAR/QSPR, ADME...
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Nova Science Publishers, 2017. — 282 p. This book examines the synthesis, properties and biological activities of antibacterials. Chapter One focuses on the recent development of biomass antibacterials. Chapter Two provides comprehensive overview on smart materials based on structured noble metals covering its various forms from ultrathin layers over discrete metal islands up to...
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John Wiley & Sons, Ltd, 2013. — 207 p. — ISBN 978-1-118-35412-4. There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one...
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Wiley, 1986. — 847 p. Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying drug stability. Treats the calculations, approximations, and estimates that are useful to the pharmacist in professional practice, and presents a collection of selected drug-stability data from the pharmaceutical literature. This Handbook makes accessible to the...
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2nd Edition. — Taylor & Francis Ltd., 1994. — 310 p. — ISBN: 0748400680. In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned...
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The Royal Society of Chemistry, 2015. — 384 p. — (RSC Drug Discovery Series 39). — ISBN 978-1-84973-186-7. Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both...
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2nd edition. — CRC Press, 2012. — 762 p. History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery. Important biosynthetic approaches to "unnatural" natural products. Anticancer Agents...
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Royal Society of Chemistry, 2017. — 335 p. — (Metallobiology). — ISBN 10 1782620648. — ISBN 13 978-1782620648. Preview ebook Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic...
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John Wiley & Sons, Ltd, 2009. — 321 p. — ISBN 978-0-470-68196-1; ISBN 978-0-470-68197-8. Feature Boxes Preface Acknowledgments Inorganic Chemistry Basics Crystal field theory Octahedral crystal field Other crystal fields Factors affecting the crystal field splitting parameter, D High- and low-spin complexes Molecular orbital theory MO diagram of molecular hydrogen MO diagram for...
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New York: John Wiley&sons, 2017. — 251 p. A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in...
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The Royal Society of Chemistry, 2015. — 789 p. Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book will help readers to...
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2nd ed.VCH-Wiley, Weinheim, 2002. – 507 p. Secondary metabolism: the building blocks and construction mechanisms The acetate pathway: fatty acids and polyketides The shikimate pathway: aromatic amino acids and phenylpropanoids The mevalonate and deoxyxylulose phosphate pathways: terpenoids and steroids Alkaloids Carbohydrates
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John Wiley & Sons, Inc., New Jersey, Canada, 2015. – 634 p. – ISBN: 1118627989. The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical...
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Wiley, 2013. — 330 p. Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been...
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John Wiley & Sons, Ltd, 2015. — 293 p. — (Advances in Pharmaceutical Technology). — ISBN 978-1-118-73451-3 (cloth). This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the...
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CRC Press, 2010. — 554 p. As a result of new statistical and mathematical approaches, improved visualization tools, and recognition by international regulatory groups, quantitative structure-activity relationships (QSARs) now play important roles in pharmacology for the design of new drugs as well as in toxicology and ecotoxicology for hazard identification and risk...
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Wiley, 2013. - 628 p. Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs...
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Springer, 2017. — 495 p. — ISBN 3662532719. Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin...
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Wiley, 2010. - 391 p. - Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in...
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Academic Press, 2016. - 474 p. - Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are...
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Rijeka: Intech. 2012. — 416 p. Contents: Preface Kojic Acid Derivatives Analysis of Protein Interaction Networks to Prioritize Drug Targets of Neglected-Diseases Pathogens Recent Applications of Quantitative Structure-Activity r Relationships in Drug Design Atherosclerosis and Antihyperlipidemic Agents Inhibitors of Serine Proteinase - Application in Agriculture and Medicine...
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Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2016. — 527 p. — (Methods and Principles in Medicinal Chemistry. Volume 67) — ISBN: 352733775X From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the...
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Springer Science & Business Media, 2006. — 290 p. Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various...
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Royal Society of Chemistry, 2012, 164 pages, ISBN: 978-1-84973-017-4 The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting...
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Springer-Verlag Berlin Heidelberg, 2008. — 176 p. ISBN 978-3-540-79728-9, e-ISBN 978-3-540-79729-6, ISSN 1862-2461. DOI 10.1007/978-3-540-79729-6. Contents . Recent Advances in Ion Channel Screening Technologies. Role of Kv7 and Cav3 Ion Channels in Pain. Potassium Channels: Oncogenic Potential and Therapeutic Target for Cancers. Pharmacological Rescue ofMutant CFTR...
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Wiley, 2018. — 565 p. Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering...
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Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA. – 2006. – 607 p. This book focuses on both structural and pharmacological analogues – that is, those analogues which have similar chemical and biological properties – although some examples are also included where the analogue is derived purely on a similar chemical or a similar biological basis (but not both). Within the book, it is...
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Wiley-VCH Verlag & Co. KGaA, Weinheim, Germany, 2015. — 258 p. — ISBN: 3527336850 The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very...
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Springer, 2018. — 222 p. — (Topics in Medicinal Chemistry 26). — ISBN 978-3-319-70838-6. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs....
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Статья. Опубликована в журнале Phys. Technol. 16 (1985) Conventional forms of drugs normally medicate the whole body, reaching healthy areas as well as diseased. However techniques are now available which are better at restricting drug action to the sites where it is needed. Controlled release preparations Recent developments Drug targeting Organ targeting Magnetic...
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6th Edition. - Springer, 2005. - 188 p. - This stimulating new edition of the well-respected title "Biochemistry and Molecular Biology of Antimicrobial Drug Action" primarily covers medically important antimicrobial agents, but also includes some compounds not in current medical use, which have been invaluable as research tools in biochemistry. Since the previous edition of this...
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Royal Society of Chemistry, 2007. — 220 р. — ISBN-13 9780854042685. This book describes the technology of freeze-drying with particular emphasis on the properties of the material to be processed, pre-freezing (formulation) and post-drying (stability and shelf life). It is the first single-author publication, centred mainly on the properties of the materials to be processed,...
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New York, USA: John Wiley and Sons, Inc., 2002. — 1014 p. — ISBN 0471407275. Drug Safety Evaluation presents an all-inclusive, practical guide for those who are responsible for ensuring the safety of drugs and biologics for patients, for health care providers, for those involved in the manufacture of medicinal products, and for all those who need to understand how the safety of...
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Taylor & Francis Group, LLC, 2008. – 504 p. – ISBN: 0849390516. As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Table of Contents . Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever Changing Climate—An Overview. Emerging Trends in Process...
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Elsevier, 2013. - 445 p. - Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting...
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Marcel Dekker, Inc., 2003. - 400 p. This book is the first of its kind that discusses extensively the welldeveloped science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that...
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2nd Edition. — Boca Raton, USA, Taylor & Francis Group, LLC, 2018. — 433 p. — (Drugs and the Pharmaceutical Sciences 217). — ISBN 1498704913. The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into...
  • №93
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Wiley, 2010. - 623 p. In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease...
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Wiley, 2014. - 476 p. - In contrast to previous texts focusing on either computational, structural or synthetic methods, this one–of–a–kind guide integrates all three skill sets for a complete picture of contemporary structure–based design. As a result, this practical book demonstrates how to develop a high–affinity ligand with drug–like properties for any given drug target for...
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Springer International Publishing, 2014. — 90 p. A discussion of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or leads to novel drugs for human use. This SpringerBrief deals with bioactive materials from terrestrial extremophiles.
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Wiley, 2005. — 644 p. 3Li Lithium Metallotherapeutics 5B Boron Compounds as Therapeutic Drugs 12Mg The Role of Magnesium as a Metallotherapeutic Drug 13Al Aluminum Metallotherapeutics 14Si Biological Activity of Organosilicon Compounds 20Ca The Role of Calcium as a Metallotherapeutic Drug 22Ti Anti-tumor Titanium Drugs 23V Insulin-Mimetic Vanadium-Containing Compounds...
  • №97
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Wiley VCH, 2018. — 777 p. — (Methods and Principles in Medicinal Chemistry. Volume 73). This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to...
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Oxford University Press, 1995 - 336 p. Drugs and the medicinal chemist The why and the wherefore Why should drugs work? Where do drugs work? Protein structure The primary structure of proteins The secondary structure of proteins The alpha helix The beta-pleated sheet The tertiary structure of proteins Covalent bonds Ionic bonds Hydrogen bonds Van der...
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CRC Press, 2018. - 311 p. Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume III is devoted to the growing variety of techniques...
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Springer, 2017. — 170 p. This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other...
  • №101
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William Andrew, 2018. — 814 p. — (Pharmaceutical Nanotechnology). — ISBN 978-0-12-813689-8 This book covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of...
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WILEY-VCH, 2000. — 363 p. Contents: Organic Synthesis and Medicinal Chemistry lk: Gualtieri Setting the Scene Classical and Bio-assisted Organic Synthesis New Strategies Oligomers Conclusion References Series Design in Synthetic Chemistry Sergio Clementi. Gabriele Cruciani. Manuel Pastor and Torbjorn Lundstedt Introduction The Multivariate Approach Design...
  • №103
  • 21,62 МБ
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Wiley-VCH, 1998. — 159 p. Writing or editing a book about a rapidly evolving area of science is a challenge. Doing this while being involved in real projects every day is even more of a challenge. And changing location and assignment during this exercise (which is true for both editors) adds further hurdles. We are thus particularly glad to now present a series of real-life...
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Wiley-VCH, 1998. — 159 p. Writing or editing a book about a rapidly evolving area of science is a challenge. Doing this while being involved in real projects every day is even more of a challenge. And changing location and assignment during this exercise (which is true for both editors) adds further hurdles. We are thus particularly glad to now present a series of real-life...
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Springer Vienna, 2013. — 478 p. Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to...
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CRC Press, 2015. — 152 p. — ISBN: 1466579986. The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to...
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Wiley-VCH, 2018. — 522 p. — ISBN: 978-3-527-67440-4. The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical...
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Wiley-VCH, 2014. — 654 p. — ePDF ISBN: 978-3-527-67655-2 The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and...
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RSC, 2003. — 149 p. The Classes of Natural Product and Their Isolation The Characterization and Determination of the Carbon Skeleton of a Natural Product The Location of the Functional Groups and the Molecular Stereochemistry Some Ezamples of Structure Elucidation The Biosynthesis of Secondary Metabolites Further Reading Answers to Problems
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Taylor & Francis Group, LLC , 2015. – 574 p. – ISBN: 9814613215. In the area of controlled release of active substances, such as drugs, a strong interest in nanoparticles as carriers of active ingredients has arisen. Some of the active components are extremely hydrophobic, without cellular permeability and susceptible to metabolic degradation. Owing to this, their use is...
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Wiley, 2006. — 426 p. Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries. With its practical approach, this is at once a guideline for development chemists...
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Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany. – 2013, 350 Pages. – ISBN: 3527329846. Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized...
  • №113
  • 10,79 МБ
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Taylor & Francis Group, 2014. - 252 p. - Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying...
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Wiley-Blackwell, — 1999. — 312 p. — ISBN 978-3-527-30092-1 Only few fields of scientific techniques had such an astonishing and wide spread development into different areas as nuclear magnetic resonance. Starting more than fifty years ago as a purely physical technique it soon entered the field of organic and inorganic chemistry, passed over to structural biology and is now...
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Royal Society of Chemistry, 2015. — 314 p. Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the...
  • №116
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International Atomic Energy Agency, 2007. — (Issue 458 of Technical reports series). — 458 p. — ISBN 9201151063, 9789201151063. Radionuclide therapy employing unsealed radiotherapeutic agents has emerged as an important tool for cancer management. A number of therapeutic radiopharmaceuticals based on different types of carrier molecule and a variety of radioisotopes are...
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Автор неизвестен. FDA, 2002. — 38 p. This guidance makes recommendations to sponsors of investigational new drugs on the parameters that should be routinely assessed in toxicology studies to determine effects of a drug on immune function, when additional immunotoxicity studies should be conducted, and when additional mechanistic information could help characterize the...
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АГМУ,Барнаул,2013,23 слайда About glycosides in general Saponins Cardiac glycosides Cyanogenic glycosides
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John Wiley & Sons Ltd , 2001. – 566 p. Toxicology is now considered to be a topic worthy of study and research in its own right, having originally arisen as a subsection of pharmacology. This rapid growth in the significance of toxicology necessitates specialised yet comprehensive information that is easily accessible both to professionals and to the increasing number of students...
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Springer, 2015. — 710 p. This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These...
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London: Royal Society of Chemistry, 2017. — 347 p. The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy...
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Springer, 2013. - 331 p. - This book will illustrate the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text will highlight recent developments from these disciplines that have delivered drugs, clinical candidates or significantly...
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Статья. Опубликована в журнале Advanced Drug Delivery Reviews, 11 (1993) 59-84 Biodegradable hydrogels have been exploited in the controlled drug delivery area due to various advantages. This review describes different types of biodegradable hydrogel systems, mechanisms and factors affecting their degradation, and their applications in drug delivery. Biodradable hydrogels were...
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Elsevier. 2007. 3295 p. Comprehansive Glycoscience brings together glycochemistry, glycoanalysis, glycobiology, glycomedicine, glyco(bio)technology, food and industrial glycoscience, and glycobioinformatics - glycoproteins, glycolipids, proteoglycans, glycosylphosphatidylinositol anchors, and polysaccharides - the microbial, animal, plant, and human world - health and disease. In...
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Статья. Опубликована в журнале Advanced Drug Delivery Reviews 47 (2001) 113–131 Recently, colloidal carrier systems have been receiving much attention in the field of drug targeting because of their high loading capacity for drugs as well as their unique disposition characteristics in the body. This paper highlights the utility of polymeric micelles formed through the...
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Springer, 2018. - 66 p. The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug...
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  • 1,57 МБ
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Wiley, 2011. - 468 p. A complete, one-stop reference to real-world antiviral drug discovery and development. The field of antiviral drugs continues to evolve at a fast pace in response to new virus discoveries and development of viral resistance to existing therapies. This book provides case histories and arms both basic and industrial pharmaceutical researchers with practical...
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  • 18,80 МБ
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Wiley-Blackwell, 2018. — 476 p. — ISBN 978-1-118-80128-4. A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status...
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  • 6,34 МБ
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Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, 2015. — 361 p. — (Methods and Principles in Medicinal Chemistry. Volume 65) — ISBN: 352733582X This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the...
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Academic Press, 2018. — 470 p. — ISBN 978-0-12-812218-1. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design...
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CRC Press, 2010. — 371 p. — ISBN: 1420073494 Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D...
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Статья. Опубликована в Journal of Controlled Release, Volume 90, Issue 2, 24 June 2003, Pages 143–162 Expandable gastroretentive dosage forms (GRDFs) have been designed for the past 3 decades. They were originally created for possible veterinary use, but later the design was modified for enhanced drug therapy in humans. These GRDFs are easily swallowed and reach a significantly...
  • №133
  • 378,22 КБ
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Springer, 2013. - 918 p. Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of...
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American Chemical Society, 2012. - 317 p. - During the past several years, it has become increasingly clear that carbohydrates, which can be targeted to specific diseases, represent a whole new dimension in drug design. Characterized by a variety of terms - specific recognition, lectins, and molecular diversity, just to cite a few - this new dimension based on carbohydrates...
  • №135
  • 15,28 МБ
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Springer, 2016. — 146 p. The book describes the individual steps necessary for biomacromolecular fragments analysis, as well as a list of essential software tools. For each step, it also shows corresponding web-based tools in detail and provides practical examples of their use. All tools and databases mentioned in the examples are available free of charge, platform-independent,...
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  • 5,12 МБ
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Taylor & Francis Group, LLC, 2013. — 378 p. — ISBN: 9814316490 Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and...
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  • 25,15 МБ
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Wiley, 2013. — 465 p. Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading...
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New York: Ellis Horwood. – 2005. – 150 p. The Department of Pharmaceutical-Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, organizes, every other year, a graduate seminar in advanced medicinal chemistry, with international participation, in Thessaloniki. The purpose of this seminar is to help young and ambitious pharmaceutical scientists in this...
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  • 2,22 МБ
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Boca Raton: CRC Press, 2001. – 333 p. As with many product developments and discoveries, this book was written as a result of a series of coincidences and circumstances. First, I was asked to make a presentation to a major pharmaceutical company on calibration weightstheir use, storage and which class should be used. From this and subsequent similar presentations, I was able...
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  • 14,24 МБ
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American Pharmacists Association (APhA), 2004. — 825 p. — ISBN 1582120315, 9781582120317. A reference for nuclear pharmacy practitioners, nuclear medicine technologists, and nuclear medicine physicians. It covers radioactive decay, radiation detection and measurement, radiation protection and risk, radiation safety, radiation biology, licensing and regulatory controls,...
  • №141
  • 206,12 МБ
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Wiley-VCH, 2012. — 1738 p. In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and...
  • №142
  • 27,71 МБ
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Springer International Publishing AG, 2017. — 210 p. — (Topics in Medicinal Chemistry 23) — ISBN: 3319489259 Наука лекарственной химии предлагает человечеству одну из своих лучших надежд на улучшение качества жизни. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of...
  • №143
  • 5,14 МБ
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New York: Taylor & Francis. – 2006. – 301 p. (Drugs and the Pharmaceutical Sciences: A Series of Textbooks and Monographs 161) Arguably the most difficult aspect of drug development, once proof-of-concept is achieved for a novel mechanism, is defining the right dose. Indeed, the question rapidly expands to right for whom? An individual? A population? A specific disease? A unique...
  • №144
  • 7,80 МБ
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Springer, 2008. — 383 p. In the last two decades, the discipline of biopharmaceutics has undergone considerable advances, particularly with regard to bioavailability and bioequivalence as they relate to product quality and regulatory standards of approval. Textbooks in the field have not been able to keep up with the growth of current and emerging applications of regulatory...
  • №145
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IOS Press, 2008. — 141 p. — (Solvay Pharmaceuticals Conferences. Volume 9) — ISBN: 1586039490 The scope of this book is that the pharmaceutical industry must change the way it operates. The editors of this book feel that the current business model is economically unsustainable and incapable to meet expectations of modern society. The number of novel medications in the global...
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  • 1,97 МБ
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Taylor & Francis Group, LLC., 2008. – 256 p. – ISBN: 0849372682. The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. Contents ....
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  • 10,69 МБ
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Kluwer Academic Publishers, 2002. — 428 p. 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum...
  • №148
  • 7,98 МБ
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Kluwer Academic Publishers, 2002. — 364 p. 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approaches, Receptor Models and Other...
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  • 12,94 МБ
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Academic Press, 2015. — 256 p. A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the...
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  • 5,11 МБ
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Статья. Опубликована в International Journal of PharmTech Research, Vol.1, No.3, pp 644-653, July-Sept 2009 Acyclovir is an antiviral drug, used for treatment of herpes simplex virus infections with an oral bioavailability of only 10 to 20 % (limiting absorption in GIT to duodenum and jejunum),half life about 3 hrs, soluble only at acidic pH (pKa 2.27). Polymeric nano drug...
  • №151
  • 238,41 КБ
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WILEY-VCH Verlag GmbH, 2006. - 375 p. Preface. A Personal Foreword. List of Contributors. Introduction. Pharmacophores: Historical Perspective and Viewpoint from a Medicinal Chemist. Pharmacophore Approaches. Pharmacophore Model Generation Software Tools. Alignment-free Pharmacophore Patterns – A Correlation-vector Approach. Feature Trees: Theory and Applications from...
  • №152
  • 5,37 МБ
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JohnWiley & Sons Ltd., 2008. — 337 p. — ISBN: 1405159685. Quantifying the environmental impact of chemical technologies and products, and comparing alternative products and technologies in terms of their "greenness" is a challenging task. In order to characterise various aspects of a complex phenomenon, a number of different indicators are selected into a metric....
  • №153
  • 7,39 МБ
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Springer Science + Business Media, 2009. — 326 pages, ISBN: 0387777180 Calcium phosphate coatings ( 50 mm thick), especially those made with hydroxyapatite (HA), produced by the plasma-spraying process have been successfully used on orthopedic and dental implants to improve fixation of these implants in bone. Thin calcium phosphate coatings ( 10 mm thick) formed by various...
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  • 10,58 МБ
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Boca Raton: CRC Press. – 2006. – 481 p. Today, identifying and validating a potential drug target involves not only numerous well-designed experiments, but also the incorporation of several in silico approaches. These in silico analyses are often predictive, offering cheaper and faster alternatives to in vitro or in vivo procedures. This book addresses the in silico technologies...
  • №155
  • 7,12 МБ
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Marcel Dekker, INC. New York Basel. 1998. - 501 p. This useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development. Shows how to overcome pharmaceutical, technological,...
  • №156
  • 20,05 МБ
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Oxford University Press, 2006. — 310 p. This is a book on the history of drug discovery. More important, this is a book about drug discoverers that highlights their intellectual splendor, as well as their human frailty. In preparing this manuscript, I have had the great fortune to communicate with some scientists who played pivotal roles in discovering the drugs we use....
  • №157
  • 3,59 МБ
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Wiley, 2006. — 477 p. Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies-developed for natural...
  • №158
  • 5,26 МБ
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Zürich: Verl. Helvetica Chimica Acta; Weinheim: Wiley-VCH, 1999. — 563 p. — ISBN 3-906390-20. The Start Platinum Complexes for the Treatment of Cancer: Why the Search Goes On Barnett Rosenberg Cisplatin How Good is it? Clinical Status of Cisplatin, Carboplatin, and Other Platinum-Based Antitumor Drugs Peter J. ODwyer, James P. Stevenson, and Steven W. Johnson How Does it Possibly...
  • №159
  • 5,43 МБ
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Springer, 2018. — 632 p. — (Springer Series in Biomaterials Science and Engineering 9). — ISBN 978-981-10-5974-2. As automobile mechanics repair damaged cars with auto parts, biomaterial researchers thereby endeavor to repair the damaged body tissue through the appropriate “parts”. With the bionic concepts, they attempt to fabricate nonlife materials to participate in the process...
  • №160
  • 26,19 МБ
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Second Edition. – Boca Raton: CRC Press. – 2008. – 685 p. This book has its origin in a training course, “The Role of Drug Solubility in Formulation Development,” offered by the American Association of Pharmaceutical Scientists, 6 years ago in Chicago. The course was designed to help young pharmaceutical scientists and pharmacy graduate students solve problems often encountered in...
  • №161
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3rd Edition. — Boca Raton, USA: CRC Press, Taylor & Francis Group, 2018. — 757 p. — ISNB-13 978-1-4987-2941-3. Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can...
  • №162
  • 26,17 МБ
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Royal Society of Chemistry, 2012, 498 pages, ISBN: 978-1-84973-166-9 This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and...
  • №163
  • 6,01 МБ
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Wiley, 2010. — 879 p. The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as...
  • №164
  • 10,51 МБ
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Weinheim, Germany: Wiley-VCH, 2013. — 406 p. — ISBN 3527332790. Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in...
  • №165
  • 4,62 МБ
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New York: Marcel Dekker, 2004. — 348 p. Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods - a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during...
  • №166
  • 7,54 МБ
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New York, Marcel Dekker, Inc., 2002. — 335 p. — ISBN: 0-8247-0804-0. Surfactant and polymer systems play an important role in modern drug delivery, where they may allow control of the drug release rate, enhance effective drug solubility, minimize drug degradation, contribute to reduced drug toxicity, and facilitate control of drug uptake. In all, they contribute significantly...
  • №167
  • 9,53 МБ
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Elsevier, 2018. — 760 p. — ISBN: 978-0-08-102081-4. This book provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active...
  • №168
  • 13,34 МБ
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Woodhead Publishing, 2015. - 260 p. In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this...
  • №169
  • 14,76 МБ
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Wiley, 2006. — 411 p. This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final–stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to...
  • №170
  • 3,11 МБ
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Springer, 2018. - 455 p. This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and...
  • №171
  • 9,96 МБ
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Cambridge University Press, 2010. - 287 p. Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR,...
  • №172
  • 34,04 МБ
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Woodhead Publishing, 2017. — 538 p. — (Woodhead Publishing Series in Biomedicine). — ISBN: 978-0-08-100625-2. This book thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm...
  • №173
  • 20,70 МБ
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CRC Press, 2018. - 315 p. This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal,...
  • №174
  • 16,43 МБ
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Smithers Rapra Technology, 2014. — 576 p. Use of polymers has become indispensable in the field of drug delivery. Polymers play a crucial role in modulating drug delivery to exploit maximum therapeutic benefits and have been fundamental in the successful development of several novel drug delivery systems that are now available. This book provides details of the applications of...
  • №175
  • 21,46 МБ
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Springer, 2019. - 414 p. This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking,...
  • №176
  • 12,51 МБ
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Springer International Publishing, 2015. — 384 p. — ISBN 978-3-319-18143-1. This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been...
  • №177
  • 9,47 МБ
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Humana Press Inc. 2004. — 372 pages ISBN: 158829515X Although it is relatively easy to determine the efficacy of a new drug, it is difficult to establish its safety when administered to millions of patients with multifaceted diseases, co-morbidities, sensitivities, and multiple drug use. In Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and...
  • №178
  • 5,48 МБ
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New Age International (P) Ltd., Publishers (New Delhi and all.), 2005. - 331 p. Язык: английский. В книге изложена информация об основных тенденциях развития медицинской химии, принципах действия лекарственных средств, взаимосвязь физико-химических свойств органических фармацевтических субстанций с их действием и метаболизмом. Рассматриваются основные фармакологические группы...
  • №179
  • 7,06 МБ
  • дата добавления неизвестна
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McGraw-Hill, 2011. — 240 p. This definitive text provides in-depth information on computer-assisted techniques for discovering, designing, and optimizing new, effective, and safe drugs. Computer-Aided Drug Design and Delivery Systems offers objective and quantitative data on the use and delivery of drugs in humans. Enabling technologies such as bioinformatics,...
  • №180
  • 1,98 МБ
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Springer-Verlag Berlin Heidelberg, 2009. - 258 p. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series should cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of...
  • №181
  • 4,79 МБ
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Springer Dordrecht Heidelberg London New York, Springer-Verlag Berlin Heidelberg. 2009, 257 p. ISSN 1862-2461 e-ISSN 1862-247X. ISBN 978-3-540-87911-4 e-ISBN 978-3-540-87912-1. DOI 10.1007/978-3-540-87912-1. Contents . Overview: Transporters as Targets for Drug Discovery. Membrane Transporters: Structure, Function and Targets for Drug Design. Design of Monoamine...
  • №182
  • 4,78 МБ
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3rd edition. — Informa Healthcare, 2010. — 420 p. This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists and...
  • №183
  • 7,98 МБ
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Springer, 2018. — 191 p. — (Advances in Experimental Medicine and Biology 1091). — ISBN 978-981-13-1369-1. This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to...
  • №184
  • 3,95 МБ
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3rd Edition. — Oxford University Press, New York, USA, 2005. — 664 p. — ISBN 0195104560. Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in...
  • №185
  • 20,37 МБ
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Elsevier, 2014. — 510 p. Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals...
  • №186
  • 25,14 МБ
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Wiley, 2017. — 564 p. — ISBN 9781119060680. Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies...
  • №187
  • 7,98 МБ
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WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008. – 522 p. –ISBN: 3527318720. Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR....
  • №188
  • 4,40 МБ
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Springer International Publishing AG, 2018. — 150 p. — (SpringerBriefs in Plant Science). — ISBN 3319742396. Licorice (Glycyrrhiza) is one of the most widely used in foods, herbal medicine and one of the extensively researched medicinal plants of the world. In traditional medicine licorice roots have been used against treating many ailments including lung diseases, arthritis,...
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  • 3,40 МБ
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Springer, 2006. Ferrari M. (ed.). BioMEMS and Biomedical Nanotechnology. Volume I: Biological and Biomedical Nanotechnology. Chapter 2. Factors Affecting Release Rates Recent Applications of Controlled Release Microspheres Fabrication of Polymer Micro- and Nanoparticles Techniques for Fabricating Uniform Microspheres Techniques for Fabricating Uniform Core-Shell...
  • №190
  • 563,86 КБ
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San Diego: ICON Health Publications, 2004. — 444 p. This is a 3-in-1 reference book. It gives a complete medical dictionary covering hundreds of terms and expressions relating to potassium. It also gives extensive lists of bibliographic citations. Finally, it provides information to users on how to update their knowledge using various Internet resources. The book is designed for...
  • №191
  • 6,25 МБ
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2nd edition. — Humana Press, 2010. — 516 p. This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
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  • 9,88 МБ
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5th ed. Oxford University Press, 2013. — 814 p. ISBN-13: 978-0199697397; ISBN-10: 0199697396 This is a popular textbook of Medicinal Chemistry in its 5th edition. Contents: Drugs and drug targets: an overview PART A Drug targets Protein structure and function Enzymes: structure and function Receptors: structure and function Receptors and signal transduction...
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  • 21,48 МБ
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Wiley, 2015. — 439 p. By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a comprehensive survey ranging from small-molecule antibiotics to antimicrobial peptides and their engineered...
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  • 3,83 МБ
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Informa Healthcare USA, Inc., 2006. — 439 p. — ISBN: 0824759249 Presenting the advantages and disadvantages of various procedures so the reader can select and utilize the most appropriate technique best-suited to their needs, this source includes references to current literature in the field and offers an opinion on future opportunities and challenges. Contents The...
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  • 34,78 МБ
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Woodhead Publishing, 2013. - 436 p. - The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this;...
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  • 9,63 МБ
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Статья. Опубликована в журнале IRJP 2 (4) 2011 38-45 The purpose of writing this review on the floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. FDDS is one of the approaches in chronotherapeutic drug delivery. In the past reviews of FDDS the physiological and...
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  • 1,27 МБ
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Challenges and Advances in Computational Chemistry and Physics (Volume 8) — Springer, 2010. — 428 p. ISBN-10: 1402097824 Recent Advances in QSAR Studies: Methods and Applications presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part of this volume is handbook-esque and consists of a comprehensive review of QSAR methodology written...
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  • 2,79 МБ
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Wiley-Blackwell, 2015. — 623 p. Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the...
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  • 15,08 МБ
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NIDA Research Monograph Series No 79, A RAUS Review Report, 1987. – 216 p. Structure-Activity Relationships in Cannabinoids: An Overview Stereochemical Requirements for Cannabimimetic Activity Structure-Activity Relationships of Tricyclic and None lass ica I Bicyclic Cannabinoids Structure-Anticonvulsant Activity Relationships of Cannabidiol Analogs Anticonvulsant and...
  • №200
  • 2,15 МБ
  • дата добавления неизвестна
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Wiley, 2009. — 316 p. The concepts, applications, and practical issues of Quality by DesignQuality by Design (QbD) is a new framework currently being implemented by the FDA, as well as EU and Japanese regulatory agencies, to ensure better understanding of the process so as to yield a consistent and high-quality pharmaceutical product. QbD breaks from past approaches in assuming...
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John Wiley & Sons, 2011. — 528 p. — ISBN 978-3-527-32669-3 Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who...
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Статья. Опубликована в журнале Nanomedicine: Nanotechnology, Biology, and Medicine 2 (2006) 8–21 Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled- and sustained-release properties, subcellular size, and biocompatibility with...
  • №203
  • 468,64 КБ
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CRC Press, 2008. - 380 p. - An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop...
  • №204
  • 14,08 МБ
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Weinheim, Germany: Wiley-VCH, 2013. — 351 p. — ISBN 3527332820. This is the first book in the field to focus on these aspects, providing extremely valuable information unavailable elsewhere for anyone seeking the practical application of microreactor technology in preparative chemistry. The topics covered branch out in three different directions. To begin with, the knowledge...
  • №205
  • 8,99 МБ
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Humana Press, 2010. — 297 p. Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead...
  • №206
  • 6,85 МБ
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Humana Press, 2019. - 563 p. This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design are...
  • №207
  • 19,99 МБ
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InTech, 2011. - 654 p. This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are...
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  • 19,20 МБ
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ITOe, 2017. — 158 p. — ISBN 9535131206. This volume is dedicated to Licorice Ingredients: Licorice extracts are used as additive to many Kampo medicines to alleviate pain and inflammation. With rapid progress of analytical methodology, its action mechanism is being elucidated. This book is composed of three sections. Section 1 introduces licorice as alternative medicine, its...
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Springer International Publishing AG, 2017. — 192 p. — (Topics in Medicinal Chemistry 21) — ISBN 3319418165. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to...
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  • 2,99 МБ
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Springer, 2017. — 318 p. — (Methods in Molecular Biology). — ISBN 978-1-4939-6561-8. miRNA Targeting Drugs: The Next Blockbusters? Functional Analysis of miRNAs Using the DIANA Tools Online Suite. Non-Nucleotide Modification of Anti-miRNA Oligonucleotides. Quantification of Oligonucleotide Association with miRNA–Argonaute Complexes In Vitro. Determination of Anti-miR Association...
  • №211
  • 11,68 МБ
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Wiley-VCH, 2013. — 578 p. — ISBN 3527334610. Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic–chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline...
  • №212
  • 8,32 МБ
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Wiley, 2012. — 346 p. — ISBN9780470588956. The ultimate reference guide to the synthesis of radiopharmaceuticals The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Volume 1 in the...
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  • 4,55 МБ
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John Wiley & Sons, 2015. — 288 p. — (Wiley Series on Radiochemical Syntheses, Radiochemical Syntheses Volume 2). — ISBN 1118834046, 9781118834046. This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used...
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  • 5,90 МБ
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Wiley, 2002. - 369 p. - Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's...
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  • 3,15 МБ
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ExLi4EvA., 2016. – 397 p. – ISBN: 9535122479. This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. The readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. This reference discusses advances in the design,...
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  • 26,54 МБ
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InTech, 2012. - 510 p. This reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals. This book collects reviews and original articles from...
  • №217
  • 14,01 МБ
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CRC Press, 2005. — 305 p. Интерес к биологически разлагаемым и рассасывающимся полимерам быстро растет, во многом из-за их использования в качестве биомедицинских имплантатов и приложений для доставки лекарств. Этот текст иллюстрирует творческие подходы к проектированию уникальных, волоконно-формовочных материалов для столь же уникальных приложений. Он включает в себя пример...
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  • 2,40 МБ
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Apple Academic Press, 2019. - 448 p. With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery. The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the...
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International Regulatory Guidelines Springler, 2011, XII, 128 p. Safety Evaluation of Pharmaceuticals and Medical Devices has been written to provide complete, ready and clear guidance as to what nonclinical safety assessment tests need to be performed to move a regulated therapeutic medical product into and through the development process and to marketing approval. This...
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Springer, 2018. — 332 p. — ISBN 9811307725. This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The...
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3rd ed. — Academic Press, 2015. — 521 p. in color. — ISBN: 9780123820303. The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many...
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  • 19,14 МБ
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Статья. Опубликована в журнале The American Journal of Clinical Nutrition, 1993;58:622-626 The present investigation was undertaken to assess the efficacy of oral iron supplementation during pregnancy by using a gastric delivery system (GDS). Three hundred seventy-six pregnant women between 16 and 35 y of age and 14 and 22 wk gestation were selected if mild anemia was present...
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  • 969,37 КБ
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Статья. Опубликована в журнале Experimental and Molecular Pathology 86 (2009) 215–223 Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the nanometer size range. These nano-sized objects, e.g., nanoparticles, take on novel properties and functions that differ markedly from those...
  • №224
  • 580,40 КБ
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Wiley, 2009. — 310 p. — (Methods and Principles in Medicinal Chemistry 42). Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug...
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Second edition. — Informa Healthcare, 2006. — 648 p. — ISBN 9780849327797. The book presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new addition updates the scientific advances in new drug discovery and development for areas such as...
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Mannhold R. , Kubinyi H. , Timmerman H. (editors). – Weinheim- New York-Chichester- Brisbane-Singapore-Toronto: Wiley VCH, 2001. – 141 p. The present volume of the series Methods and Principles in Medicinal Chemistry focuses on the impact of pharmacokinetics and metabolism in Drug Design. Pharmacokinetics is the study of the kinetics of absorption, distribution, metabolism, and...
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  • 2,31 МБ
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2th ed. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 2006. — 207 p. ISBN-13: 978-3-527-31368-6. ISBN-10: 3-527-31368-0. In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of...
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  • 1,31 МБ
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John Wiley and Sons, 2005. — 483 p. Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on...
  • №229
  • 7,00 МБ
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Thoth Press, 1998. — 257 p. — ISBN 0-9663128-3-X (2002) ISBN-13 978-0-9663128-3-6. Dedication Reader's Notice Introduction Amphetamine Laboratories Laboratory Statistics MDMA Production The Chemist Methamphetamine Laboratories Methamphetamine Terms Primary Methamphetamine Production Methods Assessment of the Threat Production With the United States Production Outside the United...
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  • 88,99 МБ
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Thoth Press, 2005. - 259 p. ISBN: 0966312864 Love Drugs is a sequel to Amphetamine Syntheses (2002) Expanded coverage of the synthesis of MDMA and other empathogens and stimulants. Expanding the chemistry of empathogens. MDMA from scratch. Small and large scale production is described in detail. Hot new formulas abound. Piperonyl-acetone from both safrol and isosafrol....
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CRC Press, 2016. — 335 p. Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of...
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  • 30,44 МБ
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The Royal Society of Chemistry, 2017. — 586 p. With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based...
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  • 27,24 МБ
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Boston: Pearson, 2013. — 438 p. Emphasizing applications of chemistry while reinforcing theory – especially in the areas of organic and physical chemistry – this new text prepares readers for career success in the pharmaceutical, medical, and biotech industries. Medicinal Chemistry: The Modern Drug Discovery Process delivers a comprehensive introduction to medicinal chemistry...
  • №234
  • 15,60 МБ
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John Wiley & Sons, Ltd., 2014. – 472 p. – ISBN: 1118488520. Increasing the potency of therapeutic compounds, while limiting side–effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy....
  • №235
  • 19,94 МБ
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Fifth Edition. — CRC Press, 2017. — 527 p. — ISBN 978-1-4987-0278-2. Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and...
  • №236
  • 23,65 МБ
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Springer, 2017. — 410 p. — ISBN 10 4431565248, 13 978-4431565246. This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients...
  • №237
  • 14,70 МБ
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Springer, 2017. — 496 p. — ISBN 10 4431565248, 13 978-4431565246. This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients...
  • №238
  • 7,03 МБ
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The Royal Society of Chemistry, 2016. — 272 p. — (RSC Green Chemistry. Volume 46) — ISBN: 1782624678 Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such...
  • №239
  • 9,03 МБ
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Springer Science+Business Media, 2015. — 122 p. — ISBN-10: 9401796904 This book provides a clearly structured introduction to hydrogen biology and medicine. Hydrogen is the one of the most abundant elements in the universe and has the simplest structure. In 2007, Japanese researchers found that the selective oxidation of hydrogen has a therapeutic effect on various diseases...
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  • 2,78 МБ
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Статья. Опубликована в журнале Acta Vet. Brno 2007, 76: 547-552 The purpose of this experiment was to develop an effective postruminal transport system (PTS) with a high content of suitable vegetable proteins and amino acids. PTS serves for nutrient delivery to the abomasum and small intestine of dairy cows in order to increase the milk yield. Direct addition of proteins and...
  • №241
  • 249,65 КБ
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InTech, 2012. - 100 p. ISBN: 9535103080 9789535103080. This volume describes a group of virtual screening methods and techniques that are used currently in modern drug discovery. Virtual Screening is directed to those interested in the different aspects of drug design that include academicians (pharmacists, chemists), and scientists at pharmaceutical companies. The first...
  • №242
  • 5,74 МБ
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Elesevier, 2006. - 7200 p. ISBN: 0080445136 The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes...
  • №243
  • 109,52 МБ
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Chichester: John Wiley & Sons, 2003. — 291 p. This book is written for second, and subsequent year undergraduates studying for degrees in medicinal chemistry, pharmaceutical chemistry, pharmacy, pharmacology and other related degrees. It is also intended for students whose degree courses contain a limited reference to medicinal chemistry. The text assumes that the reader has a...
  • №244
  • 3,80 МБ
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2nd ed. — Wiley, 2007. — 648 p. Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal...
  • №245
  • 11,96 МБ
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CRC Press, Taylor & Francis Group, 2018. — 502 p. – ISBN 1138197963. Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters, and, together with Q3D,...
  • №246
  • 32,02 МБ
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Springer New York, 2010. — 248 p. This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdose–responsestudies. The importance of this subject can be found from the International Conference on Harmonization (ICH) E4 Guidance document. Establishing the dose–response relationship is one of the most...
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Wiley, 2018. — 433 p. — ISBN 978-1-118-69621-7. An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical...
  • №248
  • 9,67 МБ
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CRC Press, 2004. - 413 p.2nd ed Table of Contents Introduction: Photostability Testing of Drugs and Drug Formulations — Why and How Photophysical and Photochemical Aspects of Drug Stability Standardization of Kinetic Studies of Photodegradation Reactions Rationalizing the Photochemistry of Drugs Technical Requirements and Equipment for Photostability Testing Photostability...
  • №249
  • 7,73 МБ
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Springer, 2008. - 484 p. - Various pharmaceutical nanocarriers, such as nanospheres, nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established...
  • №250
  • 20,81 МБ
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Wiley, 2006. - 488 p. - Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related...
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Springer, 2017. — 154 p. — ISBN 978-3-319-59503-0. Delivery of drugs through skin has been an attractive area for research and for pharmaceutical companies as it can offer larger therapeutic window compared to systemic delivery. Dermal drug development started back in the 1950s with corticosteroids as, despite impressive efficacy, corticosteroids use was limited because of the...
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  • 4,96 МБ
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2nd Edition. Springer. 2010. — 280 pages ISBN: 1441964177 New Drug Development: Second Edition provides an overview of the design concepts and statistical practices involved in therapeutic drug development. This wide spectrum of activities begins with identifying a potentially useful drug candidate that can perhaps be used in the treatment or prevention of a condition of...
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  • 3,04 МБ
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Wiley, 2007. — 298 p. Introduction New Drug Development The Regulatory Environment for New Drug Development Drug Discovery and Nonclinical Research Drug Discovery Nonclinical Research Design, Methodology, and Analysis Design and Methodology in Clinical Trials Statistical Analysis Statistical Significance: Employment of Hypothesis Testing Clinical Significance:...
  • №254
  • 14,17 МБ
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Wiley, 2014. - 453 p. - Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, "Physicochemical and Biomimetic Properties in Drug Discovery" encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug...
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  • 15,89 МБ
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Springer, 2009. — 379 p. The discipline of nuclear medicine has tremendously enriched my professional and personal life and several people have been instrumental in shaping my destiny. Professor Walter Wolf, who ignited my research interests in the development of radiopharmaceuticals, Professor Henry Wagner, Jr., the ambassador of nuclear medicine, Professor Michael Phelps, the...
  • №256
  • 10,87 МБ
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VCH Publishers, 2008. — 369 p. The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices in the planning of syntheses, and describes techniques for analyzing biological...
  • №257
  • 18,46 МБ
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Springer, 2015. - 399 p. - This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g.,...
  • №258
  • 13,52 МБ
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Springer Science+Business Media, 2015. — 167 p. Series: Advances in Experimental Medicine and Biology. Vol. 863. This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common...
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  • 4,53 МБ
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Wiley-VCH, 2017. — 756 p. — (Methods and Principles in Medicinal Chemistry,Volume 71). In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following...
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  • 11,56 МБ
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Springer, 2009. - 663. - The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be...
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  • 14,25 МБ
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John Wiley & Sons, 2007. — 480 p. Offers students taking Pharmacy and related courses an introduction to biopharmaceuticals. This work covers protein science and recombinant DNA technology. It also includes specific 'product category chapters' focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products.
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  • 10,13 МБ
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Wiley, 2011. — 441 p. This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and...
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  • 17,54 МБ
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2nd ed. — Wiley, 2016. — 738 p. — (Drug Discovery and Development). — ISBN 1118833368, 9781118833360 An indispensable tool for those working at the front lines of new drug development The development of effective delivery systems is crucial to taking a drug from the discovery and development stages to successful clinical use. The advances of recent years in the pharmaceutical...
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  • 28,81 МБ
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Wiley, 2005. - 461 p. - An indispensable tool for those working at the front lines of new drug development. Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial...
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  • 5,22 МБ
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Статья. Опубликована в J Pharm Pharmaceut Sci 10 (2): 217-230, 2007 Purpose: To study the effect of encapsulation of recombinant adenovirus type 5 encoding β-galactosidase (Ad5-βgal) in poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres on viral delivery to professional antigen presenting cells (APCs) in vitro, viral dissemination in vivo, and induction of protective immune...
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  • 152,61 КБ
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New Jersey: John Wiley & Sons, Inc., 2011-508 р. This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome....
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  • 4,15 МБ
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Springer, 2016. — xi, 487 p. Photoprotection captures the interest of physicians, academic researchers, industry scientists, law makers, marketers, general media, and consumers. It is a dynamic field where progresses and advancements often hinge on close collaboration of multidisciplinary teams. In the past decade, significant development has been made in the realm of...
  • №268
  • 12,26 МБ
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Taylor & Francis Group, 2012. - 396 p. - Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess...
  • №269
  • 15,04 МБ
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3rd ed. — Elsevier, 2008. — 982 p. Description Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making...
  • №270
  • 27,31 МБ
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Informa Healthcare, USA, Inc., 2008. — 532 p. — (Drugs and the pharmaceutical sciences 172) — ISBN 1420043870. This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also...
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  • 5,18 МБ
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Wiley, 2012. - 393 p. - Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are...
  • №272
  • 3,17 МБ
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CRC Press, 2010. — 309 p. — ISBN 1439810672, 9781439810675. Nanoengineering, energized by the desire to find specific targeting agents, is leading to dramatic acceleration in novel drug design. However, in this flurry of activity, some issues may be overlooked. This is especially true in the area of determining dosage and evaluating the effects of multiple agents designed to...
  • №273
  • 6,48 МБ
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Elsevier, 2014. -194 p. - Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting...
  • №274
  • 6,45 МБ
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Wiley, 2018. — 558 p. — ISBN 978-1-118-68633-1. A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews...
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  • 12,55 МБ
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John Wiley & Sons, Inc. 2009. - 307 p. For students interested in pursuing a career in the drug design field, this text is intended to give an ideal starting point for their studies. The text assumes a solid background in chemistry, a basic understanding of biochemistry, and nly minimal previous exposure to computational chemistry. Researchers already employed in the drug design...
  • №276
  • 15,04 МБ
  • дата добавления неизвестна
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Wiley, 2016. — 457 p. The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation...
  • №277
  • 1,85 МБ
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Wiley, 2011. — 465 p. Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology. Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and...
  • №278
  • 44,81 МБ
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Totowa, NJ.: Humana Press Inc. 2005. — 382 p. Fundamental Issues Related to Natural Product-based Drug Delivery Natural Products and Drug Discovery. Arnold L. Demain and Lixin Zhang Strategies Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products. Lixin Zhang Automated Analyses of Hplc profiles of Microbial Extracts: A new Tool for Drug Discovery...
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  • 6,80 МБ
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New York: Springer, 2016. - 290p. Features practical, hands-on instruction for the use of CADD systems Includes tips from experts in the field to ensure successful implementation Focuses on the vital early stages of the drug discovery process This detailed volume examines computer-aided drug discovery (CADD), a crucial component of modern drug discovery programs that is...
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2nd Edition. — Wiley, 2018. — 709 p. — ISBN 9781119288169. An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green...
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Wiley, 2012. — 748 p. Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign...
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Austria: Springer Berlin Heidelberg, 2007. — 354 p. SBN-10 3-540-33989-2 Springer Berlin Heidelberg New York. SBN-13 978-3-540-33989-2 Springer Berlin Heidelberg New York. Contents . Drug Safety. Technetium in Medicine. Stannous Chloride in the Preparation of Tc-99m Pharmaceuticals. Quality Assurance of Radiopharmaceuticals. Performance and Quality Control of the...
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Уфа: Гилем, 2005. — 232 с. В книге опубликованы результаты исследований в области медицинской химии, представленные на V Всероссийском научном семинаре и Молодежной научной школе «Химия и медицина», проходившем 5–8 сентября 2005 г. в Уфе. Рассмотрены вопросы химии и технологии лекарственных средств, структурного анализа, фармакологии природных биологически активных соединений и...
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Самара: Самарский государственный медицинский университет, 2016. — 254 с. Учебное пособие предназначено для студентов лечебного факультета СамГМУ и включает теоретический материал по химии в соответствии со стандартом ФГОС 3+. В нем содержатся основные сведения по биоэнергетике, теории растворов, электрохимии, физической и коллоидной химии, химии биополимеров. Приведены примеры...
  • №285
  • 6,08 МБ
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М.: Наука, 1991. —199 с. ISBN 5-02-004122-X В книге(монография) представлены результаты исследований по проблемам создания и изучения механизмов действия иммуномодуляторов. Описаны методы синтеза нового класса мурамилпептидов. Приводятся данные сравнительного изучения механизмов иммуномодулирующего действия. Рассчитана на биохимиков иммунологов. (Материал относительно...
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Томск, Национальный исследовательский томский политехнический университет, 2012 г. - 81 с. Содержание. Введение. Биофармация - теоретическая основа технологии лекарств. Основные термины и понятия фармацевтической технологии и биофармации. Биологическая доступность лекарств. Вопросы эквивалентности лекарственных препаратов. Методы оценки биодоступности in vitro....
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Учеб.-метод. пособие. — Минск : Новое знание, 2015. — 39 с. — ISBN 978-985-475-717-9. Учебно-методическое пособие посвящено актуальной проблеме наружного лечения дерматозов. Приведено большое количество прописей различных лекарственных форм для наружной терапии кожных заболеваний. Для врачей-дерматовенерологов, а также слушателей курсов переподготовки и повышения квалификации,...
  • №288
  • 385,14 КБ
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2-е изд., перераб. и доп. — Ленинград: Медгиз, 1963. — 146 с. Издание рассчитано на фармакологов и исследователей в области экспериментальной химиотерапии. Автор приводит в книге основные приемы обработки экспериментального материала, необходимые для научного работника, изыскивающего биологически активные вещества. Для практических целей прилагаются таблицы и номограммы....
  • №289
  • 2,50 МБ
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2-е изд., перераб. и доп. — Ленинград: Медгиз, 1963. — 146 с. Издание рассчитано на фармакологов и исследователей в области экспериментальной химиотерапии. Автор приводит в книге основные приемы обработки экспериментального материала, необходимые для научного работника, изыскивающего биологически активные вещества. Для практических целей прилагаются таблицы и номограммы....
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  • 2,10 МБ
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Учебное пособие. — Челябинск: Челяб. гос. ун-т., 2001. — 75 с. — ISBN 5-7271-0513-7. В данном пособие излагаются основы структурообразования и сольватации биологических жидкокристаллических систем, зависимость их свойств от конформационного и фазового состояния. Приведены спектральные характеристики, номенклатура и классификация липидов, методология их теоретического и...
  • №291
  • 2,03 МБ
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Курск: КГМУ, 2016. — 124 с. Учебное пособие содержит систематизированные вопросы и ответы на них по изучаемым темам в рамках курса химии для студентов 1 курса, обучающихся по специальностям: лечебное дело, педиатрия, стоматология, медико-профилактическое дело. Приведены ответы на ситуационные задачи и решения расчетных задач медицинской направленности. Учебное пособие...
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  • 3,47 МБ
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Актобе: редакционно-издательский отдел АГУ им. К. Жубанова, 2009. — 105 с. Учебно-методическое пособие «Химия природных соединений» предназначено для углубления и расширения знаний студентов о природных соединениях растительного происхождения, для привлечения студентов исследовательской работе. Изучение спецкурса способствует формированию у студентов лабораторно-практических...
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  • 511,92 КБ
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Учебно-методическое пособие для студентов фармацевтического факультета. — Барнаул : Алтайский государственный медицинский университет, 2009. — 188 с. Настоящее учебно-методическое пособие предназначено для самостоятельной подготовки студентов и интернов фармацевтического факультета и слушателей курсов повышения квалификации провизоров-технологов к практическим и семинарским...
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  • 1,26 МБ
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Учебник. — Днепр: Экономика, 2018. — 250 с. В соответствии с программой по технологии лекарств рассмотрены теоретические и практические аспекты современного направления в лекарствоведении – биофармации, а также достижения фармацевтической технологии, основанные на биофармацевтической концепции о биологической значимости переменных (фармацевтических) факторов. При изложении...
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  • 1,81 МБ
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Учебное пособие. Запорожье, Издательство ЗГМУ, 2005. - 223 с. В соответствии с программой по технологии лекарств рассмотрены теоретические и практические аспекты современного направления в лекарствоведении – биофармации, а также достижения фармацевтической технологии, основанные на биофармацевтической концепции о биологической значимости переменных (фармацевтических) факторов....
  • №296
  • 829,74 КБ
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Монография. — М.: Вузовская книга, 2001. — 408 с. — ISBN 5-89522-132-7. Монография состоит из двух основных разделов. В первом разделе рассматриваются взаимодействие биологически активных веществ с рецепторными системами, даны сведения о нейромедиаторах, метаболизме, проблемах фармакологии, связанных со стереохимией лекарственных соединений, обобщены данные о концепции...
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  • 14,80 МБ
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Монография. — М.: Вузовская книга, 2001. — 408 с. — ISBN 5-89522-132-7. Монография состоит из двух основных разделов. В первом разделе рассматриваются взаимодействие биологически активных веществ с рецепторными системами, даны сведения о нейромедиаторах, метаболизме, проблемах фармакологии, связанных со стереохимией лекарственных соединений, обобщены данные о концепции...
  • №298
  • 2,84 МБ
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М.: Вузовская книга, 2001. — 384 с. — ISBN 5-89522-167-Х. Учебное пособие состоит из трех основных разделов. Первый раздел, названный «Общие и теоретические проблемы», представляют собой модифицированный курс «Общей фармакологии» и посвящен обычному рассмотрению вопросов фармакокинетики и фармакодинамики, являющихся предметом курсов фармакологии, предназначенных для...
  • №299
  • 2,72 МБ
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М.: Вузовская книга, 2001. — 384 с. — ISBN 5-89522-167-Х Учебное пособие состоит из трех основных разделов. Первый раздел, названный «Общие и теоретические проблемы», представляют собой модифицированный курс «Общей фармакологии» и посвящен обычному рассмотрению вопросов фармакокинетики и фармакодинамики, являющихся предметом курсов фармакологии, предназначенных для...
  • №300
  • 7,93 МБ
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Пер. с англ.; ВОЗ. — М.: Весь Мир, 2006. — 216 с. — ISBN 5-7777-0244-9. Настоящее, седьмое, издание книги «Лекарственные средства и деньги» предоставляет разработчикам политики в области здравоохранения компактный и практический обзор различных подходов к проблеме сдерживания затрат на медикаментозное лечение в условиях роста общих расходов на здравоохранение. Представленные меры...
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Кишинев: ГУМ, 2000. — 352 с.: ил. — ISBN 9975-917-42-9. Предпринята попытка выявить роль химических и физико-химических факторов во взаимодействии между физиологически активным веществом и биологическими рецепторными системами. Подробно рассмотрены основные факторы, оказывающие непосредственное влияние на биологическую активность химического соединения, такие, как: электронные...
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  • 10,16 МБ
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Учебное пособие / Под научной редакцией Д.О. Скобелева. — М.: АСМС, 2014. — 100 с. Учебное пособие предназначено для подготовки специалистов в области проведения неклинических (доклинических) исследований медицинской и экологической безопасности объектов, содержащихся в лекарственных средствах, пестицидах, косметической продукции, ветеринарных препаратах, пищевых и кормовых...
  • №303
  • 1,29 МБ
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К.: Медицина, 2008. — 400 с. Изложены теоретические основы биоэнергетики и кинетики биохимических реакций; описаны свойства растворов и их роль в протекании биохимических процессов; приведены современные представления об электродных процессах; освещены особенности поверхностных явлений и их роль в жизнедеятельности организма, свойства дисперсных систем и растворов биополимеров....
  • №304
  • 17,15 МБ
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К.: Медицина, 2008. — 400 с. Изложены теоретические основы биоэнергетики и кинетики биохимических реакций; описаны свойства растворов и их роль в протекании биохимических процессов; приведены современные представления об электродных процессах; освещены особенности поверхностных явлений и их роль в жизнедеятельности организма, свойства дисперсных систем и растворов биополимеров....
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Підручник для студентів вищих медичних закладів освіти 3-4 рівнів акредитації. — Київ: Інтермед, 2006. — 460 с. У підручнику викладено теоретичні основи біоенергетики та кінетики біохімічних реакцій; описано властивості розчинів та їх роль у перебігу біохімічних процесів; викладено сучасні уявлення про електродні процеси, поверхневі явища та їх роль у життєдіяльності...
  • №306
  • 18,05 МБ
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Учебно-методическое пособие. Новосибирск: Сибмедиздат НГМУ, 2011. – 164 с. Учебно-методическое пособие предназначено для студентов фармацевтического факультета очной и заочной форм обучения, интернов, а также провизоров. В пособии приводятся информационные материалы по общим и частным вопросам биофармации, биофармацевтическим аспектам лекарственных форм, содержится описание...
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М.: Межакадемическое изд-во ВПК, 2005. – 608 с. ISBN 5-902313-04-X Монография посвящена биомедицинскому, формально-логическому моделированию, планированию, анализу, качеству и биобезопасности экспериментов на линейных и аутбредных животных. На большом фактическом материале даются принципы выбора адекватных животных-биомоделей для сравнительных исследований в управляющих и...
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  • 4,34 МБ
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Владивосток: Дальнаука, 2016. — 128 с. Монография посвящена исследованию биологической активности экстрактов и различных соединений, полученных из морских ежей. Интерес к этим веществам в настоящее время чрезвычайно высок в силу их разнообразной биологической активности. Авторы являются специалистами по исследованию биологически активных веществ, богатейшим источником которых...
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  • 1,49 МБ
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Екатеринбург, 1998. — 25 с. Научно-исследовательский отчет, посвященный доклиническому исследованию биологически активного спрея "Морфей", предназначенного для повышения защитных сил организма, нормализации обмена веществ и сна, в качестве профилактического и корригирующего средства заболеваний печени и желчевыводящих путей, гипертонической болезни, невротических состояний,...
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Сборник задач. — Сумы : Сумский государственный университет, 2017. — 30 с. Для студентов-иностранцев специальности 1201 «Медицина» дневной формы обучения. Темы: Комплексные соединения Растворы Термодинамика, кинетика и химическое равновесие Окислительно-восстановительные реакции. Электрохимия Коллоидная химия Список использованной литературы
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Орехово-Зуево: Государственный гуманитарно-технологический университет, 2018. — 49 с. В работе представлен анализ применимости деонтологических норм и правил содержания и использования экспериментальных животных к содержанию и использованию животных-продуцентов биологического сырья, предназначенного для производства продукции медицинского назначения, а также сформулированы...
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Харків, 2012. — 33 с. Визначення прозорості і ступеня каламутності рідин. Визначення ступеня забарвлення рідин. Потенціометричне визначення рН. Випробування лікарського засобу на стерильність. Пірогени. Аномальна токсичність. Визначення молекулярної маси. Бактеріальні ендотоксини.
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  • 271,14 КБ
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Учебное пособие. Харьков, НФаУ, 2015. - 8 с. Индивидуальные задания и ситуационные задачи по предмету Биофармация для студентов фармацевтического факультета.
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Коллектив авторов. — М.: Гриф и К, 2012. — 944 с. Настоящее издание разработано в соответствии с проводимой в Российской Федерации политикой в сфере обращения лекарственных средств, направленной на обеспечение населения эффективными и безопасными, в первую очередь отечественными лекарственными средствами, созданными на основе современных достижений биологии, медицины и...
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Учебное пособие. — К.: «Каравелла», 2008. — 156 с. — ISBN 966-8019-69-5 Рекомендовано Министерством образования и науки Украины как учебное пособие для студентов высших учебных заведений. В учебном пособии изложены современные представления по медицинской химии. Рассмотрена химия биогенных элементов, экологические аспекты окружающей среды, элементы химической термодинамики и...
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Навчальний посібник. — Київ: Каравела, 2007. — 168 с. Висвітлено проблеми медичної хімії. Розглянуто хімію біогенних елементів, екологічні аспекти навколишнього середовища, питання хімічної термодинаміки й засади хімічної кінетики. Розкрито роль комплексних сполук у живому організмі, властивості істинних розчинів, колоїдів і розчинів високомолекулярних сполук. Описано сучасні...
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Винниця: Нова книга, 2006. — 776 с. У підручнику наведено основні поняття, закони і методи загальної, біонеорганічної, фізичної та колоїдної хімії у застосуванні до медико-біологічних проблем. Розглянуто хімічні властивості біологічних елементів і комплексних снолук та їх роль у життєдіяльності організму; вчення про розчини; загальні положення аналітичної хімії; хімічну...
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Київ : Медицина, 2010. — 495 с. У підручнику на основі сучасних наукових досягнень висвітлено предмет і завдання медичної хімії, її теоретичні та практичні положення. Складається з трьох частин. У першій частині викладено теоретичні основи загальної хімії, зокрема вчення пр розчини, поняття, класифікацію та фізико-хімічні параметри генних і біогенних елементів, роль макро- і...
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Екатеринбург: Изд‑во Урал. ун-та, 2015. — 156 с. — ISBN 978-5-7996-1576-5 В пособии рассматриваются методы синтеза биологически активных соединений ароматического ряда, а также соединений, относящихся к классам терпенов и стероидов. Описываются механизмы действия некоторых лекарственных средств и приводятся сведения о применении природных и синтетических карбоциклических...
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Харьков: Фолио, 2005. — 461 с. В учебнике кратко изложены основные понятия клеточной, молекулярной биологии и биохимии (строение клетки и биологических мембран, функции ферментов, нуклеиновых кислот, вторичных посредников), необходимые химикам для рассмотрения вопросов общей фармакологии (фармакодинамики, фармакокинетики, метаболизма лекарственных средств). Кроме того, в него...
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  • 4,11 МБ
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Учебник. — Харьков: УкрФА, 1999. — 461 с. — ISBN: 966-615-024-7. OCR В первом томе учебника рассмотрены теоретические и практические аспекты создания, изучения, производства, контроля качества, реализации, хранения и применения лекарств, а также государственного регулирования всех видов предпринимательской деятельности в фармацевтической отрасли. При изложении материала уделено...
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Учебник. — Харьков: УкрФА, 1999. — 442 с. — ISBN 966-615-024-7. OCR Во втором томе учебника рассмотрены теоретические и практические аспекты производства лекарств с жидкой дисперсионной средой (растворов, суспензий, эмульсий, экстракционных лекарств из растительного сырья), в том числе инъекционных и офтальмологических, лекарств с пластично-упруго-вязкой средой (мазей,...
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М.: Наука, 1988. — 208 с. — ISBN 5-02-004031-2. В монографии обсуждаются молекулярные механизмы возникновения, развития и нормализации патологических состояний, структурные различия входящих в состав организма биополимеров в норме и при патологии. Анализируются молекулярные механизмы действия фармакологических препаратов, проблемы лигаидной патологии и хелатной фармакологии....
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Петропавловск: СКГУ им.М.Козыбаева, 2013. — 105 с. — ISBN 978-601-272-452-3. Рассмотрены новые данные о трансдермальных терапевтических системах, о химическом составе лекарственных веществ и способах получения фитопленок. Представлены результаты физико-химического и фармакологического исследования фибриновых фитопленок в области хирургии и стоматологии. Книга предназначена для...
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Киев: Наукова Думка, 1969. — 232 с. В книге впервые обобщены основные физико-химические принципы использования высокодисперсных глинистых минералов в фармацевтической и медицинской практике. Показана роль кристаллической структуры глинистых минералов и их коллоидно-химических свойств при получении самых разнообразных фармацевтических препаратов. Приведены основные принципы...
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Волгоград: изд-во ВолГМУ, 2009. — 98 с. В монографии рассмотрены основные современные подходы и методы в исследовании закономерностей взаимосвязи структура – биологическая активность соединений для осуществления целенаправленного синтеза на примере производных коричной кислоты и близких структурных аналогов. Показана прямая и достоверная взаимосвязь между проявлением...
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Вінниця : ВНМУ, 2010. — 36 с. Зміст: Теплові ефекти хімічних реакцій. Спрямованість процесів. Кінетика біохімічних процесів. Хімічна рівновага. Метод потенціометричного аналізу. Окиснювально – відновні або редокс – системи. Будова колоїдної частинки (міцели).
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3-е изд. — М.: Мир; БИНОМ. Лаборатория знаний, 2007. -191 с: ил. В учебном издании изложены основы органической химии лекарственных веществ, которые нашли применение в практической медицине в XX в. Отражено развитие химии лекарственных веществ, рассмотрены современная стратегия синтеза фармакологически активных соединений и методология отбора среди них эффективных лекарственных...
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М.: Химия, 2001. — 192 с. — ISBN 5-7245-1184-3 В книге изложены основы органической химии лекарственных веществ, которые нашли применение в практической медицине в 20-м веке. Отражена эволюция химии лекарственных веществ, рассмотрена современная стратегия синтеза фармакологически ценных соединений, освещена методология поиска среди них эффективных лекарственных препаратов....
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Учебно-методические пособие. Запорожье, Издательство ЗГМУ, 2008. - 60 с. Учебно-методическое пособие для студентов V курса по специальности «Фармация» по «Биофармации» составлено в соответствии с программой по дисциплине. Учебно-методическое пособие составлено согласно той структуры исследований, которая используется в практике доклинического изучения при создании новых...
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Иркутск: Иркутсвкий унт-т, 2003. - 40 с. Пособие знакомит с новым методом получения биологически активных органических соединений - комбинаторным синтезом. Этот метод позволяет быстро создавать молекулярные множества - библиотеки соединений, что в сочетании с успехами геномики и развитием методов высокопроизводительного скрининга служит основой современной химии лекарственных...
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Тихонов А.И., Ярных Т.Г. 3упанец И.А. и др. — Под ред. Тихонов А.И. Учебник. — Харьков: Золотые страницы, 2003. — 240 с.: ил. — Для студентов фармацевтических вузов и факультетов. ISBN 966-615-191-Х. ISBN 966-8032-92-6. В учебнике приведены современные сведения по биофармации: основные термины и понятия, фармацевтические факторы и их содержание, различные аспекты...
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Учебное пособие для студентов вузов. Харьков: Изд-во НФаУ: Золотые станицы, 2003. - 96 с. Практикум по биофармации предназначен для аудиторной работы студентов, включает практические задания, теоретические вопросы и алгоритмы действия но каждой теме, а также итоговое семинарское занятие с обобщающими теоретическими вопросами, тестами, ситуационными задачами. Рекомендовано для...
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  • 4,23 МБ
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Харьков: изд-во НФаУ «Золотые страницы», 2003. — 241 с. В учебнике приведены современные сведения по биофармации: основные термины и понятия, фармацевтические факторы и их содержание, различные аспекты биологической доступности лекарственных веществ, фармако-технологические методы оценки распадаемости, растворения и высвобождения лекарственных веществ из лекарственных...
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  • 2,71 МБ
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Харьков: НФаУ; Оригінал, 2005. — 184 с. — ISBN: 966-615-241-х. Язык: Украинский. Методичні рекомендації призначені для працівників практичної фармації і медицини. У виданні наведено технологію, аналіз, зберігання й застосування екстемпоральних розчинів для ін'єкцій, очних крапель, а також очних мазей та лікарських препаратів з антибіотиками, які об'єднані асептичними умовами...
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М.: Ремедиум, 2000. - 398 с. В руководстве описаны правила проведения доклинических испытаний разрабатываемых лекарственных веществ, описаны правила GLP (надлежащей лабораторной практики), принятые в Российской федерации, представлены указания по изучению общетоксического действия, аллергизирующих, мутагенных, канцерогенных свойств, репродуктивной токсичности и иммунотоксического...
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  • 4,34 МБ
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Углублённый курс для студентов. — Пер. с англ. — М.: Мир, 1966. — 648 с. Эта книга предназначена для студентов, уже знакомых с основами органической химии и желающих углубить свои знания. Как и в моей предыдущей книге («Advanced Organic Chemistry»), основное внимание уделяется реакциям органических соединений. Отражены крупные успехи, которые были достигнуты благодаря применению...
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Второе изд., перераб. и доп. — М.: Медицина, 2005. — 832 с. Издание содержит правовые акты, методические рекомендации по проведению доклинических исследований и подготовке регистрационного досье необходимого для регистрации нового фармакологического препарата. Нормативные и правовые акты. Доклинические исследования безопасности лекарственных средств. Доклинические исследования...
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  • 48,78 МБ
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Второе изд., перераб. и доп. - М.: Медицина, 2005. - 832 с. Издание содержит правовые акты, методические рекомендации по проведению доклинических исследований и подготовке регистрационного досье необходимого для регистрации нового фармакологического препарата. Нормативные и правовые акты. Доклинические исследования безопасности лекарственных средств. Доклинические...
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  • 5,34 МБ
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Учебное пособие. — Томск: Томский политехнический университет, 2008. — 81 с. В пособии рассмотрены методы создания систем для адресной доставки лекарственных препаратов и биологических молекул, пролонгирования их эффекта. На конкретных примерах представлена технология получения и работы пролонгированных лекарственных форм с использованием различных носителей, созданных на основе...
  • №341
  • 1,06 МБ
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Учебное пособие. Томск: Лаборатория оперативной полиграфии СибГМУ, 2006. — 75 с. Учебное пособие отражает основные положения науки, изучающей биологическое действие лекарственных препаратов в зависимости от фармацевтических факторов. Пособие включает общий теоретический материал и методические указания по проведению четырёх лабораторных занятий по биофармацевтической оценке...
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  • 1,14 МБ
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М.: Арнебия, 2006. — 288 с. Пер. с немецкого. ISBN 5-9244-0041-7 Содержание: Воздействие на биохимические и метаболические процессы в организме путем применения витаминов и микроэлементов уже давно применяется в медицине в рамках профилактики и терапии За счет использования данного класса средств врач расширяет своей арсенал методов лечения Особо нужно отметить, что...
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  • 4,41 МБ
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М.: Арнебия, 2006. — 288 с. Пер. с немецкого. ISBN 5-9244-0041-7 Содержание: Воздействие на биохимические и метаболические процессы в организме путем применения витаминов и микроэлементов уже давно применяется в медицине в рамках профилактики и терапии За счет использования данного класса средств врач расширяет своей арсенал методов лечения Особо нужно отметить, что...
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Руководство. — М.: Арнебия, 2006. - 288 с. Содержание: Воздействие на биохимические и метаболические процессы в организме путем применения витаминов и микроэлементов уже давно применяется в медицине в рамках профилактики и терапии За счет использования данного класса средств врач расширяет своей арсенал методов лечения Особо нужно отметить, что назначение микроэлементов и...
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Практическое руководство для провизоров и семейных врачей. — Харьков: Золотые страницы, 2002. — 264 с. — ISBN 966 -8032 -15 -2. Предназначено для работников практической фармации и медицины, а также для использования в качестве учебного пособия студентами фармацевтических вузов и факультетов. Содержание: Введение. Фармацевтическая опека — новое направление...
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  • 1,36 МБ
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Киев: Наукова думка, 2003. — 417 с. — ISBN 966-00-0185-1. Содержание: Структура и физико-химические свойства поверхности кремнезема. Химическое модифицирование кремнезема. Иммобилизированные на поверхности кремнезема ферменты и их применение. Теоретическое исследование взаимодействия дисперсных оксидов с биомолекулами. Термодинамика и кинетика адсорбции биоактивных...
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Яхонтов Л.Н., Глушков Р.Г. — Под ред. А. Г. Натрадзе. М.: Медицина, 1983. — 272 с. В монографии описаны пути поиска, методы синтеза, даны характеристики более 80 новых медикаментов, включенных в Государственный реестр СССР и в основном освоенных отечественной химико-фармацевтической промышленностью. Материал изложен в 8 главах по классам химических соединений. Для каждого...
  • №348
  • 1,84 МБ
  • дата добавления неизвестна
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Яхонтов Л.Н., Глушков Р.Г. — Под ред. А. Г. Натрадзе. М.: Медицина, 1983. — 272 с. В монографии описаны пути поиска, методы синтеза, даны характеристики более 80 новых медикаментов, включенных в Государственный реестр СССР и в основном освоенных отечественной химико-фармацевтической промышленностью. Материал изложен в 8 главах по классам химических соединений. Для каждого...
  • №349
  • 11,36 МБ
  • дата добавления неизвестна
  • изменен
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