NMR spectroscopy. Lecture course

Авто и выходные данные отсутствуют. 142 страницы.
Качественный курс лекций по ЯМР спектроскопии на английском языке. Содержит как вступительные так и более углублённые разделы по ЯМР спектроскопии. Может использоватся студентами химических, физических и других специальнотей в качестве справочника по ЯМР спектроскопии.
Оглавление:
The physical basis of the NMR experiment
-The Bloch equations
-Quantum-mechanical treatment
-The macroscopic view
-Fourier Transform NMR
-The interaction between the magnetization and the additonal RF (B1) field
-Description of the effect of the B1 field on transverse and lon-gitudinal magnetization using the Bloch equations
-The excitation profile of pulses
-Relaxation
-The intensity of the NMR signal
Practical Aspects of NMR
-The components of a NMR instrument
-The magnet system
-The probehead
-The shim system
-The lock-system
-The transmitter/receiver system
-Basic data acquisition parameter
-Acquisition of 1D spectra
-Calibration of pulse lengths
-Adjusting the bandwidth of the recorded spectrum
Data processing
-Phase Correction
-Zero-filling and the resolution of the spectrum
-Resolution enhancement and S/N improvement
-Exponential multiplication
-Lorentz-to-Gauss transformation
-Sine-Bell apodization
Baseline Correction
-Linear prediction
-The chemical shift
-The diamagnetic effect
-The paramagnetic term
-Chemical shift anisotropy
-Magnetic anisotropy of neighboring bonds and ring current shifts
-Electric field gradients
-Hydrogen bonds
-Solvent effects
-Shifts due to paramagnetic species
Scalar couplings
-Direct couplings (1J)
-Geminal couplings (2J)
-Vicinal couplings (3J)
-Long-range couplings
-Couplings involving p electrons
-The number of lines due to scalar spin,spin couplings
-Strong coupling
Relaxation
-T1 relaxation
-T2 relaxation
-The mechanisms of relaxation
-Other relaxation mechanisms
-Chemical shift anisotropy (CSA)
-Scalar relaxation
-Quadrupolar relaxation
-Spin-rotation relaxation
-Interaction with unpaired electrons
-The motional properties
-The dependence of the relaxation rates on the fluctuating fields in x,y or z direction
-Excurs: The Lipari-Szabo model for motions
-The nature of the transitions
-Measurement of relaxation times
The Nuclear Overhauser Effect (NOE)
-Experiments to measure NOEs
-The steady-state NOE
-Extreme narrowing (hmax 0)
-Spin-diffusion (hmax 0)
-The transient NOE
-The state of the spin system and the density matrix
-The sign of the NOE
-Why only zero- and double-quantum transitions contribute to the NOE
-Practical tips for NOE measurements
Chemical or conformational exchange
-Two-site exchange
-Fast exchange
-The slow exchange limit
-The intermediate case
-Investigation of exchange processes
-EXSY spectroscopy
-Saturation transfer
-Determination of activation parameters
The product operator formalism (POF) for description of pulse-experiments
-RF pulses
-Chemical shift precession
-Scalar spin,spin coupling
-A simple one-dimensional NMR experiment
-The effect of 180 degree pulses
-Coherence transfer
-Polarization transfer
Two-Dimensional NMR Spectroscopy
-The preparation period
-The evolution period
-The mixing period
-The detection period
-Hetcor and inverse-detection experiments
-Phasecycling
-An Alternative: Pulsed Field Gradients
-Hybrid 2D techniques
-Overview of 2D experiments
-Original references for 2D experiments
Solid State NMR Spectroscopy
-The chemical shift
-Dipolar couplings
-Magic Angle Spinning (MAS)
-Sensitivity Enhancement
-Recoupling techniques in SS-NMR
-SS-NMR of oriented samples
-Labeling strategies for solid-state NMR applications