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Murray R.K., Granner D.K., Mayes P.A., Rodwell V.W. Harper's Illustrated Biochemistry

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Murray R.K., Granner D.K., Mayes P.A., Rodwell V.W. Harper's Illustrated Biochemistry
26th edition. The McGraw-Hill Companies, Inc. 2003. - 693 p.
The text is divided into two introductory chapters (Biochemistry & Medicine and Water & pH) followed by six main sections.
Section I deals with the structures and functions of proteins and enzymes, the workhorses of the body. Because almost all of the reactions in cells are catalyzed by enzymes, it is vital to understand the properties of enzymes before considering other topics.
Section II explains how various cellular reactions either utilize or release energy, and it traces the pathways by which carbohydrates and lipids are synthesized and degraded. It also describes the many functions of these two classes of molecules.
Section III deals with the amino acids and their many fates and also describes certain key features of protein catabolism.
Section IV describes the structures and functions of the nucleotides and nucleic acids, and covers many major topics such as DNA replication and repair, RNA synthesis and modification, and protein synthesis. It also discusses new findings on how genes are regulated and presents the principles of recombinant DNA technology.
Section V deals with aspects of extracellular and intracellular communication. Topics covered include membrane structure and function, the molecular bases of the actions of hormones, and the key field of signal transduction.
Section VI consists of discussions of eleven special topics: nutrition, digestion, and absorption; vitamins and minerals; intracellular traffic and sorting of proteins; glycoproteins; the extracellular matrix; muscle and the cytoskeleton; plasma proteins and immunoglobulins; hemostasis and thrombosis; red and white blood cells; the metabolism of xenobiotics; and the Human Genome Project.
Contents
Authors
Preface
Biochemistry & Medicine
Robert K. Murray, MD, PhD

Water & pH
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD

SECTION I. STRUCTURES & FUNCTIONS OF PROTEINS & ENZYMES
Amino Acids & Peptides
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD

Proteins: Determination of Primary Structure
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
Proteins: Higher Orders of Structure
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
Proteins: Myoglobin & Hemoglobin
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
Enzymes: Mechanism of Action
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
Enzymes: Kinetics
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
Enzymes: Regulation of Activities
Victor W. Rodwell, PhD, & Peter J. Kennelly, PhD
SECTION II. BIOENERGETICS & THE METABOLISM OF CARBOHYDRATES & LIPIDS
Bioenergetics: The Role of ATP
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc

Biologic Oxidation
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc

The Respiratory Chain & Oxidative Phosphorylation
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc

Carbohydrates of Physiologic Significance
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD

Lipids of Physiologic Significance
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc

Overview of Metabolism
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
The Citric Acid Cycle: The Catabolism of Acetyl-CoA
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
Glycolysis & the Oxidation of Pyruvate
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
Metabolism of Glycogen
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
Gluconeogenesis & Control of the Blood Glucose
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
Peter A. Mayes, PhD, DSc, & David A. Bender, PhD
Biosynthesis of Fatty Acids
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Oxidation of Fatty Acids: Ketogenesis
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Metabolism of Unsaturated Fatty Acids & Eicosanoids
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Metabolism of Acylglycerols & Sphingolipids
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Lipid Transport & Storage
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Cholesterol Synthesis, Transport, & Excretion
Peter A. Mayes, PhD, DSc, & Kathleen M. Botham, PhD, DSc
Integration of Metabolism – the Provision of Metabolic Fuels
David A. Bender, PhD, & Peter A. Mayes, PhD, DSc .
SECTION III. METABOLISM OF PROTEINS & AMINO ACIDS

Biosynthesis of the Nutritionally Nonessential Amino Acids
Victor W. Rodwell, PhD
.
Catabolism of Proteins & of Amino Acid Nitrogen
Victor W. Rodwell, PhD
Catabolism of the Carbon Skeletons of Amino Acids
Victor W. Rodwell, PhD
Conversion of Amino Acids to Specialized Products
Victor W. Rodwell, PhD

Porphyrins & Bile Pigments
Robert K. Murray, MD, PhD
SECTION IV. STRUCTURE, FUNCTION, & REPLICATION OF INFORMATIONAL MACROMOLECULES
Nucleotides

Victor W. Rodwell, PhD

Metabolism of Purine & Pyrimidine Nucleotides
Victor W. Rodwell, PhD

Nucleic Acid Structure & Function
Daryl K. Granner, MD
.
DNA Organization, Replication, & Repair
Daryl K. Granner, MD, & P. Anthony Weil, PhD

RNA Synthesis, Processing, & Modification
Daryl K. Granner, MD, & P. Anthony Weil, PhD

Protein Synthesis & the Genetic Code
Daryl K. Granner, MD
Regulation of Gene Expression
Daryl K. Granner, MD, & P. Anthony Weil, PhD

Molecular Genetics, Recombinant DNA, & Genomic Technology
Daryl K. Granner, MD, & P. Anthony Weil, PhD

SECTION V. BIOCHEMISTRY OF EXTRACELLULAR & INTRACELLULAR COMMUNICATION
Membranes: Structure & Function

Robert K. Murray, MD, PhD, & Daryl K. Granner, MD
The Diversity of the Endocrine System
Daryl K. Granner, MD

Hormone Action & Signal Transduction
Daryl K. Granner, MD

SECTION VI. SPECIAL TOPICS

Nutrition, Digestion, & Absorption

David A. Bender, PhD, & Peter A. Mayes, PhD, DSc
Vitamins & Minerals
David A. Bender, PhD, & Peter A. Mayes, PhD, DSc
Intracellular Traffic & Sorting of Proteins
Robert K. Murray, MD, PhD

Glycoproteins
Robert K. Murray, MD, PhD

The Extracellular Matrix
Robert K. Murray, MD, PhD, & Frederick W. Keeley, PhD
Muscle & the Cytoskeleton
Robert K. Murray, MD, PhD

Plasma Proteins & Immunoglobulins
Robert K. Murray, MD, PhD

Hemostasis & Thrombosis
Margaret L. Rand, PhD, & Robert K. Murray, MD, PhD

Red & White Blood Cells
Robert K. Murray, MD, PhD

Metabolism of Xenobiotics
Robert K. Murray, MD, PhD
.
The Human Genome Project
Robert K. Murray, MD, PhD

Appendix

Index
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