Nelson D.L., Cox M.M. Lehninger Principles of Biochemistry
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4th edition. — W.H. Freeman and Company, 2004. — 1119 p.The fourth edition of Lehninger Principles of Biochemistry stays true to the vision of its predecessors while embracing the advances made in biochemical research since the previous edition. As always, the book presents the fundamentals of biochemistry through selected topics, and emphasizes the most important recent developments and applications without abandoning the classical core of the subject. The new edition has been carefully streamlined to reduce the length of the book without compromising content. As with previous editions, it emphasizes clear prose and student-friendly explanations to optimize student comprehension. It also contains a groundbreaking new treatment of metabolic regulation, up-to-date coverage of DNA-based information technologies, many new applications and problems, and a new graphical style for enzyme reaction mechanisms, including step-by-step annotations that clarify the concepts and chemical logic of enzymatic reactions.Contents The Foundations of Biochemistry Cellular Foundations Chemical Foundations Physical Foundations Genetic Foundations Evolutionary FoundationsStructure and Catalysis Water Weak Interactions in Aqueous Systems Ionization of Water, Weak Acids, and Weak Bases Buffering against pH Changes in Biological Systems Water as a Reactant The Fitness of the Aqueous Environment for Living Organisms Amino Acids, Peptides, and Proteins Amino Acids Peptides and Proteins Working with Proteins The Covalent Structure of Proteins Protein Sequences and Evolution The Three-Dimensional Structure of Proteins Overview of Protein Structure Protein Secondary Structure Protein Tertiary and Quaternary Structures Protein Denaturation and Folding Protein Function Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors Enzymes An Introduction to Enzymes How Enzymes Work Enzyme Kinetics as An Approach to Understanding Mechanism Examples of Enzymatic Reactions Regulatory Enzymes Carbohydrates and Glycobiology Monosaccharides and Disaccharides Polysaccharides Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids Carbohydrates as Informational Molecules: The Sugar Code Working with Carbohydrates Nucleotides and Nucleic Acids Some Basics Nucleic Acid Structure Nucleic Acid Chemistry Other Functions of Nucleotides DNA-Based Information Technologies DNA Cloning: The Basics From Genes to Genomes From Genomes to Proteomes Genome Alterations and New Products of Biotechnology Lipids Storage Lipids Structural Lipids in Membranes Lipids as Signals, Cofactors, and Pigments Working with Lipids Biological Membranes and Transport The Composition and Architecture of Membranes Membrane Dynamics Solute Transport across Membranes Biosignaling Molecular Mechanisms of Signal Transduction Gated Ion Channels Receptor Enzymes G Protein-Coupled Receptors and Second Messengers Multivalent Scaffold Proteins and Membrane Rafts Signaling in Microorganisms and Plants Sensory Transduction in Vision, Olfaction, and Gustation Regulation of Transcription by Steroid Hormones Regulation of the Cell Cycle by Protein Kinases Oncogenes, Tumor Suppressor Genes, and Programmed Cell DeathBioenergetics and Metabolism Principles of Bioenergetics Bioenergetics and Thermodynamics Phosphoryl Group Transfers and ATP Biological Oxidation-Reduction Reactions Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway Glycolysis Feeder Pathways for Glycolysis Fates of Pyruvate under Anaerobic Conditions: Fermentation Gluconeogenesis Pentose Phosphate Pathway of Glucose Oxidation Principles of Metabolic Regulation, Illustrated with Glucose and Glycogen Metabolism The Metabolism of Glycogen in Animals Regulation of Metabolic Pathways Coordinated Regulation of Glycolysis and Gluconeogenesis Coordinated Regulation of Glycogen Synthesis and Breakdown Analysis of Metabolic Control The Citric Acid Cycle Production of Acetyl-CoA (Activated Acetate) Reactions of the Citric Acid Cycle Regulation of the Citric Acid Cycle The Glyoxylate Cycle Fatty Acid Catabolism Digestion, Mobilization, and Transport of Fats Oxidation of Fatty Acids Ketone Bodies Amino Acid Oxidation and the Production of Urea Metabolic Fates of Amino Groups Nitrogen Excretion and the Urea Cycle Pathways of Amino Acid Degradation Oxidative Phosphorylation and Photophosphorylation Oxidative Phosporylation Electron-Transfer Reactions in Mitochondria ATP Synthesis Regulation of Oxidative Phosphorylation Mitochondrial Genes: Their Origin and the Effects of Mutations The Role of Mitochondria in Apoptosis and Oxidative Stress Photosynthesis: Harvesting Light Energy General Features of Photophosphorylation Light Absorption The Central Photochemical Event: Light-Driven Electron Flow ATP Synthesis by Photophosphorylation Carbohydrate Biosynthesis in Plants and Bacteria Photosynthetic Carbohydrate Synthesis Photorespiration and the C and CAM Pathways Biosynthesis of Starch and Sucrose Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan Integration of Carbohydrate Metabolism in the Plant Cell Lipid Biosynthesis Biosynthesis of Fatty Acids and Eicosanoids Biosynthesis of Triacylglycerols Biosynthesis of Membrane Phospholipids Biosynthesis of Cholesterol, Steroids, and Isoprenoids Biosynthesis of Amino Acids, Nucleotides, and Related Molecules Overview of Nitrogen Metabolism Biosynthesis of Amino Acids Molecules Derived from Amino Acids Biosynthesis and Degradation of Nucleotides Integration and Hormonal Regulation of Mammalian Metabolism Tissue-Specific Metabolism: The Division of Labor Hormonal Regulation of Fuel Metabolism Long Term Regulation of Body Mass Hormones: Diverse Structures for Diverse FunctionsInformation Pathways Genes and Chromosomes Chromosomal Elements DNA Supercoiling The Structure of Chromosomes DNA Metabolism DNA Replication DNA Repair DNA Recombination RNA Metabolism DNA-Dependent Synthesis of RNA RNA Processing RNA-Dependent Synthesis of RNA and DNA Protein Metabolism The Genetic Code Protein Synthesis Protein Targeting and Degradation Regulation of Gene Expression Principles of Gene Regulation Regulation of Gene Expression in Prokaryotes Regulation of Gene Expression in Eukaryotes
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5th edition. — W.H. Freeman and Company. — 1515 p.
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Authors: Murray R.K., Bender D.A., Botham K.M., Kennelly P.J., Rodwell V.W., Weil P.A.
The biochemistry text that every medical student must own - now in full color! Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease....
5th ed. — W.H. Freeman and Company. 2008. — 1294 p.
The Foundation of Biochemistry
Structure and Catalysis
Amino Acids, Peptides, and Proteins
The Three-Dimensional Structure of Proteins
Carbohydrates and Glycobiology
Nucleotides and Nucleic Acids
DNA-Based Information Technologies
Biological Mambranes and Transport...
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Clear writing and illustrations…Clear explanations of difficult concepts…Clear communication of the ways in biochemistry is currently understood and practiced. For over 35 years, in edition after bestselling edition, Principles of Biochemistry has put those defining principles into practice, guiding students through a...