Kaltashov Igor A., Wang Shunhai, Wang G. Mass Spectrometry in Biopharmaceutical Analysis

De Gruyter, 2022. — 648 p. — ISBN 9783110545067.Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.Analytical chemistry in biopharma
A brief overview of biological mass spectrometry: concepts and definitions
Characterization of covalent structure of protein therapeutics
Characterization of higher order structure and protein interactions
Biosimilars and comparability studies
Characterization of impurities in biopharmaceutical products
Quantitation of protein therapeutics in biological samples
Non-protein biopharmaceuticals and related macromolecular drugs
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