Vanhaelen Quentin (ed.) Computational Methods for Estimating the Kinetic Parameters of Biological Systems

Humana Press, 2022. — 384 p. — (Methods in Molecular Biology 2385). — ISBN 978-1-0716-1766-3.This detailed book provides an overview of various classes of computational techniques, including machine learning techniques, commonly used for evaluating kinetic parameters of biological systems. Focusing on three distinct situations, the volume covers the prediction of the kinetics of enzymatic reactions, the prediction of the kinetics of protein-protein or protein-ligand interactions (binding rates, dissociation rates, binding affinities), and the prediction of relatively large set of kinetic rates of reactions usually found in quantitative models of large biological networks. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of expert implementation advice that leads to successful results. Authoritative and practical, Computational Methods for Estimating the Kinetic Parameters of Biological Systems will be of great interest for researchers working through the challenge of identifying the best type of algorithm and who would like to use or develop a computational method for the estimation of kinetic parameters.Current Approaches of Building Mechanistic Pharmacodynamic Drug–Target Binding Models
An Extended Model Including Target Turnover, Ligand–Target Complex Kinetics, and Binding Properties to Describe Drug–Receptor Interactions
Beyond the Michaelis–Menten: Bayesian Inference for Enzyme Kinetic Analysis
Multi-Objective Optimization Tuning Framework for Kinetic Parameter Selection and Estimation
Relationship Between Dimensionality and Convergence of Optimization Algorithms: A Comparison Between Data-Driven Normalization and Scaling Factor-Based Methods Using PEPSSBI
Dynamic Optimization Approach to Estimate Kinetic Parameters of Monod-Based Microalgae Growth Models
Automatic Assembly and Calibration of Models of Enzymatic Reactions Based on Ordinary Differential Equations
Data Processing to Probe the Cellular Hydrogen Peroxide Landscape
Computational Methods for Structure-Based Drug Design Through System Biology
Model Setup and Procedures for Prediction of Enzyme Reaction Kinetics with QM-Only and QM:MM Approaches
The Role of Ligand Rebinding and Facilitated Dissociation on the Characterization of Dissociation Rates by Surface Plasmon Resonance (SPR) and Benchmarking Performance Metrics
Computational Tools for Accurate Binding Free-Energy Prediction
Computational Alanine Scanning Reveals Common Features of TCR/pMHC Recognition in HLA-DQ8-Associated Celiac Disease
Umbrella Sampling-Based Method to Compute Ligand-Binding Affinity
Creating Maps of the Ligand Binding Landscape for Kinetics-Based Drug Discovery
Prediction of Protein–Protein Binding Affinities from Unbound Protein Structures
Parameter Optimization for Ion Channel Models: Integrating New Data with Known Channel Properties