Grobmyer Stephen R., Moudgil Brij M. (eds.) Cancer Nanotechnology: Methods and Protocols

Humana Press, 2010. — 395 p. — (Methods in Molecular Biology 624). — ISBN 978-1-60761-608-5.Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular Biology series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.What Is Cancer Nanotechnology?
Molecular-Targeted Therapy for Cancer and Nanotechnology
Enhanced Permeability and Retention (EPR) Effect for Anticancer Nanomedicine Drug Targeting
Nanoparticle Characterization for Cancer Nanotechnology and Other Biological Applications
Multimodal Nanoparticulate Bioimaging Contrast Agents
Gold Nanocages for Cancer Imaging and Therapy
Nanoshells for Photothermal Cancer Therapy
Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy
Polymeric Micelles: Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)-Based Micelles as an Example
Fluorescent Silica Nanoparticles for Cancer Imaging
Polymeric Nanoparticles for Drug Delivery
Synthesis, Characterization, and Functionalization of Gold Nanoparticles for Cancer Imaging
Identification of Pancreatic Cancer-Specific Cell-Surface Markers for Development of Targeting Ligands
Preparation and Characterization of Doxorubicin Liposomes
PEGylated Nanocarriers for Systemic Delivery
Nanoparticle–Aptamer Conjugates for Cancer Cell Targeting and Detection
Targeting of Nanoparticles: Folate Receptor
Magnetic Aerosol Targeting of Nanoparticles to Cancer: Nanomagnetosols
LHRH-Targeted Nanoparticles for Cancer Therapeutics
Antibody Targeting of Nanoparticles to Tumor-Specific Receptors: Immunoliposomes
Photoacoustic Tomography for Imaging Nanoparticles
Current Applications of Nanotechnology for Magnetic Resonance Imaging of Apoptosis
Applications of Gold Nanorods for Cancer Imaging and Photothermal Therapy
Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells
Colloidal Gold: A Novel Nanoparticle for Targeted Cancer Therapeutics