Elsevier Inc., 2016. — 375 p. — ISBN: 978-0-12-802184-2 Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area.Contents Practical Considerations in Mechanochemical Organic Synthesis A Historical Perspective Modern Laboratory Instrumentation for Mechanosynthesis Contamination From Wear in Organic Mechanosynthesis Analysis and Monitoring of Mechanochemical Reactions Carbon–Carbon Bond- Forming Reactions Heck Coupling Suzuki Coupling Sonogashira Coupling Glaser Coupling Michael Reaction Aldol Condensation Morita–Baylis–Hillman Reaction Knoevenagel Condensation Barbier Allylation Gewald Reaction Pinacol Reaction Grignard and McMurry Reactions Grignard–Zerewitinoff-Like Reaction Wittig Reaction Horner–Wadsworth–Emmons Reaction Asymmetric Alkylation Olefin Cross-Metathesis Cross-Dehydrogenative Coupling Reformatsky Reaction Cascade Reactions Arylaminomethylation Naphthopyran Synthesis Carbon–Nitrogen Bond-Formation Reactions 1,2-Dione/Diamine Condensation Synthesis of Imines Synthesis of (Thio)semicarbazones Synthesis of Oximes Synthesis of Hydrazones Synthesis of Azines Amide and Thioamide Bond Formation Synthesis of Nitrones Synthesis of Enamines and Enamine Ketones Alkylation of Nitrogen Synthesis of Biguanides and Guanidines Additions to Double and Triple Bonds Substitution Reactions N-Arylation of Amines Biginelli Reaction Nitroso Bond Formation/Dissociation Carbon—Oxygen and Other Bond-Formation Reactions C—O Bond Formation Reactions Sulfur Bond Formation Reactions Halogen Bond Formation Reactions Phosphorus Bond Formation Reactions Boron Bond Formation Reactions Silicon Bond Formation Reactions Bismuth Bond Formation Reactions C—H Bond Formation: Hydrogenation Multistep Mechanochemical Reaction Cycloaddition Reactions Diels–Alder Reaction 1,3-Dipolar Cycloadditions Oxidations and Reductions Oxidations Reductions Applications of Ball Milling in Nanocarbon Material Synthesis Functionalization of Fullerenes Functionalization of Single-Walled Carbon Nanotubes Functionalization of Graphenes Applications of Ball Milling in Supramolecular Chemistry Rotaxanes Complexation of Fullerenes Experiments for Introduction of Mechanochemistry in the Undergraduate Curriculum Green Chemistry at the University Level Selected Experiments Author Index Subject Index
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