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Strachan Tom, Read Andrew P. (eds.) Human Molecular Genetics

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Strachan Tom, Read Andrew P. (eds.) Human Molecular Genetics
5th edition. — CRC Press, 2019. — 1762 p. — ISBN 9780367002503
Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the ‘go-to’ book for those studying human molecular genetics or genomics courses around the world.
Basics of DNA, Chromosomes, Cells, Development, and Inheritance
Basic Principles of Nucleic Acid Structure and Gene Expression.
Fundamentals of Cells and Chromosomes.
Fundamentals of Cell-Cell Interactions and Immune System Biology.
Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells.
Patterns of Inheritance.
Understanding Genomes
Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing.
Analyzing the Structure and Expression of Genes and Genomes.
Principles of Genetic Manipulation of Mammalian Cells.
Uncovering the Architecture and Workings of the Human Genome.
Gene Regulation and the Epigenome.
Genetic Variation Between Individuals and Species
An Overview of Human Genetic Variation.
Human Population Genetics.
Comparative Genomics and Genome Evolution.
Human Evolution.
Human Genetic Disease
Chromosomal Abnormalities and Structural Variants.
Molecular Pathology: Connecting Phenotypes to Genotypes.
Mapping and Identifying Genes for Monogenic Disorders.
Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis.
Cancer Genetics and Genomics.
Applied Human Molecular Genetics
Genetic Testing in Healthcare and the Law.
Model Organisms and Modeling Disease.
Genetic Approaches to Treating Disease.
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