Chantilly: The Teaching Company, 2019. — 414 p.One of the triumphs of modern science has been our ever-improving understanding of how life works—how chemical reactions at the cellular level account for respiration, digestion, reproduction, locomotion, and a host of other living processes. This exciting subject is biochemistry—and its allied field of molecular biology. In the past century, progress in these complementary disciplines has been astonishing, and a week rarely passes without major advances in medicine, physiology, genetics, nutrition, agriculture, or other areas, where biochemistry and molecular biology are shedding new light on life.Contents :
Professor Biography Course Scope Acknowledgments Biochemistry: A Young Science Molecules and Minerals Proteins and Enzymes Cells as Houses for Reactions Water’s Electronegativity Water’s Polarity Water’s Ability to Ionize R Groups and Chiral Compounds Nonpolar, Hydrophobic Amino Acids Polar, Hydrophilic Amino Acids The Amino Acid Alphabet The Primary Structure of a Protein Secondary Structure Tertiary Structure Quaternary Structure Protein Folding Helper Proteins Protein Folding Gone Wrong Flexible Proteins Carrying Oxygen Carrying Protons and Carbon Dioxide Adult versus Fetal Hemoglobin Sickle Cell Anemia Enzymes as Catalysts Enzyme Energy Enzyme Specificity Enzyme Velocity How Cells Regulate Enzymes Allosteric Regulation Covalent Modification Physical Inhibition Fatty Acids Triacylglycerols Glycerophospholipids Sphingolipids What Are Sugars? Why Do Sugars Appeal to Us? How Do Cells Make Glucose? Problems Caused by Sugar ATP and Oxidation Using Thermodynamics Determining ∆G Sugar Glycolysis Fatty Acid Oxidation The Role of Energy Extraction Reactions of the Citric Acid Cycle Connections to Other Metabolic Pathways The Structure of Mitochondria The Electron Transport Chain Oxidative Phosphorylation Oxygen: Key to Both Processes The Light Reactions of Photosynthesis Gluconeogenesis Glycogenesis The Pentose Phosphate Pathway The Synthesis of Fatty Acids Key Steps in Cholesterol Synthesis Cellular Membranes Lipoprotein Complexes Regulation of Metabolic Pathways The Role of Electron Transport Fermentation —How Plants Make Carbs and Other Metabolites The Calvin Cycle Photorespiration Secondary Metabolites Nitrogen Fixation Amino Acids Nucleotides Free Radicals Oxidative Stress The Gut Microbiome Cellular Signals The Stress-Response System Cell Division The Nervous System Neurotransmitters Serotonin and Dopamine Taste Smell Vision Hearing Touch Caffeine Fructose Alcohol Exercise Genetic Inheritance Aging DNA Instructions for Making Proteins Storing and Copying Information RNA DNA Replication Replication in Bacteria PCR in the Lab —Chromosome Replication, Telomeres, Aging Telomeres Aging —DNA Mismatch and Excision Repair Sources of Mutation and Damage to DNA Mismatch Repair Excision Repair Other Sources of Genetic Mutation and Damage Cell Division Swapping and Recombination DNA Repair Antibody Creation Gene Inactivation and Editing Copying RNA Making RNA Transcription in Prokaryotes Transcription in Eukaryotes —Translating RNA into Proteins Inventory for Protein Production Stages of Protein Synthesis Protein Delivery Prokaryotic Gene Expression Eukaryotic Gene Expression Epigenetic Control Gene Expression after Transcription —Human Genetic Disease and Gene Therapy Hemophilia Cystic Fibrosis Alzheimer’s Disease Leber Hereditary Optic Neuropathy Unregulated Cell Division Proto-Oncogenes Tumor Suppressors Approaches to Treating Cancer Recombinant DNA Stem Cells Therapeutic Cloning Designer Genomes Genome Sequencing Cataloguing Variations in Genomes Other Omics Answers Bibliography
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