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Gussak I., Antzelevitch C. et al. (eds.) Cardiac Repolarization: Bridging Basic and Clinical Science

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Gussak I., Antzelevitch C. et al. (eds.) Cardiac Repolarization: Bridging Basic and Clinical Science
Humana Press, 2003. — 549 p. — (Contemporary Cardiology) — ISBN: 978-1-58829-069-4
The past decade has seen an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic matrix. Cardiac Repolarization: Bridging Basic and Clinical Science comprehensively reviews all the latest developments in cardiac electrophysiology, focusing on both clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions, among them early repolarization and short QT interval, Brugada syndrome, long QT syndrome, and sudden infant death syndrome. Chapters delineate objectives and key points, and include established and evidence-based knowledge, current perspectives, areas of controversy, and recommendations for future investigations.Comprehensive and clinically oriented, Cardiac Repolarization: Bridging Basic and Clinical Science surveys the major research discoveries that have recently transformed our understanding of cardiac electrophysiology and spells out in full detail their clinical implications for the diagnosis and treatment of patients with malignant electrical instability of the heart.
Introduction
Ventricular Repolarization and the Identification of the Sudden Death Candidate
Historical Milestones of Electrical Signal Recording and Analysis
Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization
Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization
Electrophysiology and Pharmacology of Ventricular Repolarization
How Do We Measure Repolarization Inside the Heart?
Contribution of Electrical Heterogeneity of Repolarization to the ECG
Electrical and Structural Remodeling of the Ventricular Myocardium in Disease
Ischemia-Related Changes in Repolarization
The Long QT Syndrome
Ion Channel Disease as a Cause of the Brugada Syndrome
Cellular and Ionic Mechanisms Underlying Arrhythmogenesis
Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice
Evaluation of Ventricular Repolarization: The Clinician's Perspective
Human Cardiac Repolarization
QT Interval and Its Drug-Induced Prolongation
Neuro-Mediated Repolarization Abnormalities
The Electrophysiologic Matrix
Antiarrhythmic Drugs and Future Direction
Specific Electrocardiographic Phenomena and Clinical Syndromes of Ventricular Repolarization
ECG Phenomena of the Early Ventricular Repolarization
The Brugada Syndrome
Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome
Prolonged Repolarization and Sudden Infant Death Syndrome
Short QT Interval
T-Wave Alternans
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