Springer, 2010. — 490 p. — ISBN: 978-1-4419-6657-5Biomedical, pharmaceutical and medical personnel are interested in studying aspects of arrhythmias at a basic, translational and applied level. The overall understanding of the molecular basis of disease has dramatically increased, as well as the number of available and emerging molecular, pharmacological and device treatment based therapies. Cardiac Electrophysiology Methods and Models will review key research methods and protocols in cardiac electrophysiology with a focus on advantages, pitfalls, practical implementation and collaborative cross-functional research.Clinical Cardiac Electrophysiology: An Overview of Its Evolution Overview Basic Cardiac Electrophysiology: Excitable Membranes Cardiac Action Potentials, Ion Channels, and Gap Junctions Anatomy and Physiology of the Cardiac Conduction System The Electrocardiogram and Clinical Cardiac Electrophysiology Methods and Models Principles of Electrophysiological In Vitro Measurements Cardiac Cellular Electrophysiological Modeling Computer Modeling of Electrical Activation: From Cellular Dynamics to the Whole Heart Detection and Measurement of Cardiac Ion Channels Cell Culture Models and Methods Isolated Tissue Models Isolated Heart Models Small Animal Models for Arrhythmia Studies Use of Large Animal Models for Cardiac Electrophysiology Studies Optical Mapping and Calcium Imaging Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods Invasive Electroanatomical Mapping and Navigation Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiography Traditional Electrophysiological Mapping Multi-channel System for Analysis of Cardiac Rhythmicity and Conductivity In Vitro Cardiac CT/MRI Imaging for Electrophysiology Putting It All Together Introduction to Translational Research Clinical Perspective: Electrophysiology in the Young and Patients with Congenital Heart Disease
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