Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2003. - 956 p. - ISBN 3-527-30632-3.To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: Chemical Synthesis of Carbohydrates Carbohydrate Biosynthesis and Metabolism Carbohydrate Analysis Cellular Functions of Carbohydrates Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.Volume 1 Complex Carbohydrate Synthesis The Chemistry of Sialic Acid Solid-Phase Oligosaccharide Synthesis Solution and Polymer-supported Synthesis of Carbohydrates Enzymatic Synthesis of Oligosaccharides Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology Chemistry and Biochemistry of Asparagine-linked Protein Glycosylation Conformational Analysis of C-Glycosides and Related Compounds Synthetic Lipid A Analogs for Sepsis Treatment Polysialic Acid Vaccines Synthetic Carbohydrate-based Vaccines Antithrombotics Based on Synthetic OligosaccharidesVolume 2 Sequencing of Oligosaccharides and Glycoproteins Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes Glycosyltransferase Inhibitors RNA-Aminoglycoside Interactions Glycosylated Natural Products Small Molecule Inhibitors of the Sulfotransferases Carbohydrate-based Treatment of Cancer Metastasis N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-influenza Agents Carbohydrate-based Drug Discovery in the Battle Against Bacterial Infections
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