Pan Stanford Publishing Pte. Ltd., 2018. — 269 p. — ISBN 978-1-315-10191-0This book explores the author’s wide-ranging work on muscle research, which spans more than 50 years. It delves into the dogmas of muscle contraction: how the models were constructed and what was overlooked during the process, including their resulting shortcomings. The text stimulates general readers’ and researchers’ interest, highlights the author’s pioneering work on the electron microscopic recording of myosin head power and recovery strokes, and presents a frank discussion on how the original work sometimes tends to be overlooked by competing scientists, who hinder the progress of science.Historical Background Dogmas of Huxley-Simmons Model not Supported Experimentally New Methods and New Dogmas and Their Shortcomings The Swinging Lever Arm Hypothesis: A Most Prominent Current Dogma Dynamic Electron Microscopy on Myosin Head Movement Using Quick-Freeze, Deep-Etch Replica Method Electron Microscopic Recording of ATP-Induced Myosin Head Movement Evidence against Current Dogmas of Muscle Contraction as Revealed by the Effect of Antibodies to Myosin Head Electron Microscopic Recording of Myosin Head Power Stroke: Possible Sequence of Actin-Myosin Interaction in Muscle The Fenn Effect : A Fundamental Mystery in Muscle Load-Dependent Mechanical Efficiency of Myosin Heads Past History Dependence of Myosin Head Performance Reminiscences of My Early Work I. Summation of Force Responses in Muscle Reminiscences of My Early Work II. Transverse Spread of Contraction Initiated by Local Membrane Depolarization in Single Muscle Fibers
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