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Gasser S.M., Li E. (Eds.) Epigenetics and Disease: Pharmaceutical Opportunities

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Gasser S.M., Li E. (Eds.) Epigenetics and Disease: Pharmaceutical Opportunities
Springer, 2011. — 270 p. — (Progress in Drug Research 67). — ISBN 978-3-7643-8988-8, 978-3-7643-8989-5.
Discusses new approaches to pharmaceutical intervention
Includes new findings from stem cell research
With numerous illustrations
Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
Table of contents
DNA Methylation and Cancer
Genome-Wide Epigenetic Modifications in Cancer
DNA Repair and the Control of DNA Methylation
Errors in Erasure: Links Between Histone Lysine Methylation Removal and Disease
Histone Modifications in Cancer Biology and Prognosis
Dynamics of Histone Lysine Methylation: Structures of Methyl Writers and Erasers
Epigenetic Mechanisms of Mental Retardation
Histone and DNA Modifications in Mental Retardation
HDAC Inhibitors and Cancer Therapy
Epigenetic Mechanisms in Acute Myeloid Leukemia
The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential
Transcriptional Regulatory Networks in Embryonic Stem Cells
Small Molecules in Cellular Reprogramming and Differentiation
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