Academic Press, 2014. — 635 p. — ISBN 978-0-12-417114-5, 9780124171343, 0124171346, 1306902541, 9781306902540, 0124171141.Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry.The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms.Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discoveryReadership This work is aimed at biomedical researchers of graduate level and above who are seeking to elucidate the epigenetic basis of psychiatric disorders. These researchers typically fall within biological psychiatry, neuroscience, epigenetics, molecular biology, and geneticists working on psychiatric disease.PrefaceGeneral Aspects of Epigenetics in Psychiatry Introduction to Epigenetics in Psychiatry Outline of Epigenetics A Brief History of Epigenetics in Psychiatry Roles of Epigenetics in the Neural Stem Cell and Neuron Role of Epigenetics in the Brain Epigenetic Epidemiology of Psychiatric Disorders Laboratory Techniques in Psychiatric Epigenetics Laboratory Epigenetic Models of Schizophrenia Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
Epigenetics of Psychiatric Disorders 5-Methycytosine and 5-Hydroxymethylcytosine in Psychiatric Epigenetics Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy Non-Coding RNAs and Psychiatric Disorders Epigenetics of Bipolar Disorder Epigenetics in Major Depressive Disorder The Epigenetics of Suicide: The Critical Impact of the Environment on Epigenetic Regulation in Suicide Epigenetics in Posttraumatic Stress Disorder Epigenetics and Cognitive Disorders Epigenetics in Intellectual Disability Epigenetics and Pervasive Developmental Disorders Epigenetics in Child Psychiatry Epigenetic Mechanisms of Drug Addiction Vulnerability Mitoepigenetics and Neuropsychiatric Disorders
Epigenetic Therapy of Psychiatric Disorders Epigenetic Effects of Currently Used Psychotropic Drugs DNA Methyltransferase Inhibitors and Psychiatric Disorders Histone Deacetylase Inhibitors and Psychiatric Disorders
Other Topics in Epigenetics in Psychiatry The Social Environment and Epigenetics in Psychiatry Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
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