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Peedicayil J., Grayson D.R., Avramopoulos D. (Eds.) Epigenetics in psychiatry

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Peedicayil J., Grayson D.R., Avramopoulos D. (Eds.) Epigenetics in psychiatry
Academic Press, 2014. — 635 p. — ISBN 978-0-12-417114-5, 9780124171343, 0124171346, 1306902541, 9781306902540, 0124171141.
Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry.
The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms.
Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction
Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein
Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery
Readership
This work is aimed at biomedical researchers of graduate level and above who are seeking to elucidate the epigenetic basis of psychiatric disorders. These researchers typically fall within biological psychiatry, neuroscience, epigenetics, molecular biology, and geneticists working on psychiatric disease.
Preface
General Aspects of Epigenetics in Psychiatry
Introduction to Epigenetics in Psychiatry
Outline of Epigenetics
A Brief History of Epigenetics in Psychiatry
Roles of Epigenetics in the Neural Stem Cell and Neuron
Role of Epigenetics in the Brain
Epigenetic Epidemiology of Psychiatric Disorders
Laboratory Techniques in Psychiatric Epigenetics
Laboratory Epigenetic Models of Schizophrenia
Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders

Epigenetics of Psychiatric Disorders
5-Methycytosine and 5-Hydroxymethylcytosine in Psychiatric Epigenetics
Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
Non-Coding RNAs and Psychiatric Disorders
Epigenetics of Bipolar Disorder
Epigenetics in Major Depressive Disorder
The Epigenetics of Suicide: The Critical Impact of the Environment on Epigenetic Regulation in Suicide
Epigenetics in Posttraumatic Stress Disorder
Epigenetics and Cognitive Disorders
Epigenetics in Intellectual Disability
Epigenetics and Pervasive Developmental Disorders
Epigenetics in Child Psychiatry
Epigenetic Mechanisms of Drug Addiction Vulnerability
Mitoepigenetics and Neuropsychiatric Disorders

Epigenetic Therapy of Psychiatric Disorders
Epigenetic Effects of Currently Used Psychotropic Drugs
DNA Methyltransferase Inhibitors and Psychiatric Disorders
Histone Deacetylase Inhibitors and Psychiatric Disorders

Other Topics in Epigenetics in Psychiatry
The Social Environment and Epigenetics in Psychiatry
Transgenerational (Heritable) Epigenetics and Psychiatric Disorders
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