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Tollefsbol T. (Ed.) Transgenerational Epigenetics

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Tollefsbol T. (Ed.) Transgenerational Epigenetics
Academic Press, 2014. — 396 p. — ISBN 978-0-12-405944-3, 0124059449.
Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.
Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.
Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes
Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies
Covers history, future outlook, disease management and current controversies
Readership
Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disorders
Preface
Transgenerational Epigenetics
Definition of Epigenetic Transgenerational Inheritance and Biological Impacts
Historical Perspective of Transgenerational Epigenetics
Epigenetics and the Maternal Germline
Epigenetic Changes in the Paternal Germline
Epidemiology of Transgenerational Epigenetics
Metastable Epialleles
Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance: Insights from Transgenic Mice
Histone-Mediated Transgenerational Epigenetics
Heritable Generational Epigenetic Effects through RNA
Animal Models of Transgenerational Epigenetic Effects
Plant Models of Transgenerational Epigenetic Inheritance
Transgenerational Hormonal Imprinting in the Unicellular Tetrahymena
Evolutionary Perspectives on Transgenerational Epigenetics
Inheritance of Epigenome Variants Across Generations and its Implications on the Emergence of Phenotypic Novelties During Evolution
Maternal Epigenetic Inheritance and Stress During Gestation: Focus on Brain and Behavioral Disorders
Paternal Epigenetic Inheritance
Transgenerational Epigenetics of Endocrine-Disrupting Chemicals
Transgenerational Effects of Perinatal Hormonal Imprinting
Phenotypic and Epigenetic Inheritance Across Multiple Generations in Mammals Through the Female Line
Transgenerational Epigenetic Inheritance of Type 2 Diabetes
Epigenetic Transgenerational Inheritance of Reproductive Disease
Cardiovascular Disease and Transgenerational Epigenetic Effects
Mental Disorders and Transgenerational Epigenetics
Clinical Aspects of Transgenerational Epigenetics
Transgenerational Epigenetics: Current Controversies and Debates
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