Academic Press, 2014. — 396 p. — ISBN 978-0-12-405944-3, 0124059449.Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversiesReadership Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disordersPreface Transgenerational Epigenetics Definition of Epigenetic Transgenerational Inheritance and Biological Impacts Historical Perspective of Transgenerational Epigenetics Epigenetics and the Maternal Germline Epigenetic Changes in the Paternal Germline Epidemiology of Transgenerational Epigenetics Metastable Epialleles Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance: Insights from Transgenic Mice Histone-Mediated Transgenerational Epigenetics Heritable Generational Epigenetic Effects through RNA Animal Models of Transgenerational Epigenetic Effects Plant Models of Transgenerational Epigenetic Inheritance Transgenerational Hormonal Imprinting in the Unicellular Tetrahymena Evolutionary Perspectives on Transgenerational Epigenetics Inheritance of Epigenome Variants Across Generations and its Implications on the Emergence of Phenotypic Novelties During Evolution Maternal Epigenetic Inheritance and Stress During Gestation: Focus on Brain and Behavioral Disorders Paternal Epigenetic Inheritance Transgenerational Epigenetics of Endocrine-Disrupting Chemicals Transgenerational Effects of Perinatal Hormonal Imprinting Phenotypic and Epigenetic Inheritance Across Multiple Generations in Mammals Through the Female Line Transgenerational Epigenetic Inheritance of Type 2 Diabetes Epigenetic Transgenerational Inheritance of Reproductive Disease Cardiovascular Disease and Transgenerational Epigenetic Effects Mental Disorders and Transgenerational Epigenetics Clinical Aspects of Transgenerational Epigenetics Transgenerational Epigenetics: Current Controversies and Debates
Чтобы скачать этот файл зарегистрируйтесь и/или войдите на сайт используя форму сверху.