Springer-Verlag, 2015. — 230 p. — (Epigenetics and Human Health). — ISBN 978-3-642-31973-0, 978-3-642-31974-7.Contains translational medicine aspects such as B cell programming and reprogramming in cancer Includes extensive glossary Understanding stem cell formation is key to develop novel drugsThe ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.Table of contentsThe Oocyte Determinants of Early Reprogramming Stella and Zygotic Reprogramming Histone Variants and Reprogramming in Early Development DNA Methylation Reprogramming in Preimplantation Development Establishing and Maintaining Pluripotency: An Epigenetic Perspective Epigenetic Regulation of Pluripotency by Polycomb Group Proteins PRC1-Mediated Gene Silencing in Pluripotent ES Cells: Function and Evolution The Biology and Genomic Localization of Cytosine Modifications Epigenetic Reprogramming in Cancer
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