Pan Stanford Publishing Pte. Ltd., 2017. — 482 p. — ISBN: 9781315364421Chemical exchange saturation transfer (CEST) imaging, a burgeoning field of magnetic resonance imaging (MRI), is only at the beginning of exploring some of the many possible applications and technology developments. The rapid expansion that CEST imaging has seen over the past 16 years since the seminal Ward and Balaban paper in 2000 has created a need for a graduate-level handbook that describes the wide assortment of issues that come into play when trying to apply CEST imaging to medicine. These issues include the fundamental principles of saturation transfer, the key features of the dia CEST, para CEST, lipo CEST, and hyper CEST agents that enable the production of imaging contrast, and the practical aspects of preparing image acquisition and post-processing schemes suited for the application. An appreciation for the expansion of this field can be found in the CEST MRI publication statistics as follows, obtained from the Web of Science in April 2016. Contents From The 1960s To The 2010s: How Saturation Transferwas First Discovered And Then Migrated Into Imaging Discovery of the “Saturation Transfer” Method Development of Chemical Exchange Saturation Transfer in Bethesda History of In Vivo Exchange Transfer Spectroscopy and Imaging in Baltimore Early Discovery and Investigations of para CEST Agents in Dallas Birth of CEST Agents in Torino Pulse Sequence, Imaging, and Post-Processing Schemes for Detecting Cest Contrast General Theory of CEST Image Acquisition and Post-Processing Uniform-MT Method to Separate CEST Contrast from Asymmetric MT Effects Hyper CEST Imaging Diacest/Paracest/Lipocest Contrast Probes Current Landscape of dia CEST Imaging Agents Evolution of Genetically Encoded CEST MRI Reporters: Opportunities and Challenges Para CEST Agents: Design, Discovery, and Implementation Transition Metal para CEST Probes as Alternatives to Lanthanides Responsive para CEST MRI Contrast Agents and Their Biomedical Applications Saturating CompartmentalizedWater Protons: Liposomeand Cell-Based CEST Agents Emerging Clinical Applications of Cest Imaging Principles and Applications of Amide Proton Transfer Imaging Cartilage and Intervertebral Disc Imaging and Glycosaminoglycan Chemical Exchange Saturation Transfer (gag CEST) Experiment Gluco CEST: Imaging Glucose in Tumors Creatine Chemical Exchange Saturation Transfer Imaging Iodinated Contrast Media as pH-Responsive CEST Agents
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