Wiley, Canada, 2016. — 562 p. — ISBN-10: 1118299841Glycans – biomolecules that are often conjugated with carbohydrates – modulate processes like cancer progression, immune response and cell-to-cell communication. However, deciphering their molecular processes is difficult because carbohydrates have complex structures and the variety in their assembly and syntheses has always been challenging. There have been many advances over the past couple of decades in glycochemistry that reduce time and material lost during purification and procedures. With new technologies and updated techniques in the field, scientists continue to better understand the role of sugars, especially in applications like drug development, candidate vaccine preparations, and probing mechanisms in living systems. As research sheds more light on the field of glycochemistry, the advances also become more available and useful to general chemists and biologists. Offering a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry; Glycochemical Synthesis: Strategies and Applications emphasizes the advances and updates from the last few years and illustrates them with key examples. It begins with fundamental synthetic aspects and expands to specific solutions to challenges in oligosaccharide assembly, strategies to the design and synthesis of sugars, techniques in the preparation of glycoconjugates, and the contributions of carbohydrate synthesis to understanding structure–activity relationships and multivalency. A valuable and complete reference about techniques and synthetic design for a major class of biomolecule, Glycochemical Synthesis offers a number of key benefits that include: Notable examples like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field Discussion of practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development A comprehensive and concise resource for readers interested in synthetic carbohydrate chemistry Topics Biochemistry Materials Science Organic Chemistry Physical & Theoretical Chemistry Contents Glycochemistry: Overview and Progress Protecting Group Strategies in Carbohydrate Synthesis General Aspects in O‐Glycosidic Bond Formation Controlling Anomeric Selectivity, Reactivity, and Regioselectivity in Glycosylations Using Protecting Groups Stereocontrolled Synthesis of Sialosides Strategies for One‐Pot Synthesis of Oligosaccharides Automated Oligosaccharide Synthesis: Techniques and Applications Sugar Synthesis by Microfluidic Techniques Chemoenzymatic Synthesis of Carbohydrates Synthesis of Glycosaminoglycans Chemical Glycoprotein Synthesis Synthesis of Glycosphingolipids Synthesis of Glycosylphosphatidylinositol Anchors Synthesis of Bacterial Cell Envelope Components Discoveries and Applications of Glycan Arrays Synthesis and Applications of Glyconanoparticles, Glycodendrimers, and Glycoclusters in Biological Systems Design and Synthesis of Carbohydrates and Carbohydrate Mimetics as Anti‐Influenza Agents Design and Synthesis of Ligands and Antagonists of Siglecs as Immune Response Modifiers Sugar–Protein Hybrids for Biomedical Applications
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