Kobeissy F., Dixon C.E., Hayes R.L., Mondello S. (Eds.) Injury Models of the Central Nervous System: Methods and Protocols

Springer Science+Business Media, 2016. — 769 p. — (Methods in Molecular Biology 1462). — ISBN: 1493938142This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers’ horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury – Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline.The History and Evolution of Experimental Traumatic Brain Injury Models
General Consideration in Using a Nimal Laboratory in CNS Injury Research
Clinical Traumatic Brain Injury in the Preclinical Setting
Rodent Models of Traumatic Brain Injury: Methods and Challenges
Traumatic Brain Injury Models in Animals
Systematic Review of Traumatic Brain Injury Animal Models
Methods of Drug Delivery in Neurotrauma
Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing
Cellular Mechanisms and Behavioral Outcomes in Blast- Induced Neurotrauma: Comparing Experimental Setups
Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury
Role of Systems Biology in Brain Injury Biomarker Discovery: Neuroproteomics Application
Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury — Models
The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol
Weight Drop Models in Traumatic Brain Injury
Midline (Central) Fluid Percussion Model of Traumatic Brain Injury
Lateral (Parasagittal) Fluid Percussion Model of Traumatic Brain Injury
Impact Acceleration Model of Diffuse Traumatic Brain Injury
Experimental Models for Neurotrauma Research
A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration
Pediatric Rodent Models of Traumatic Brain Injury
Modeling Pediatric Brain Trauma: Piglet Model of Controlled Cortical Impact
Thromboembolic Model of Cerebral Ischemia and Reperfusion in Mice
Animal Stroke Model: Ischemia–Reperfusion and Intracerebral Hemorrhage
Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury
Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults
Microdialysis as Clinical Evaluation of Therapeutic Hypothermia in Rat Subdural Hematoma Model
Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury
Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia
Experimental Models Combining Traumatic Brain Injury and Hypoxia
Animal Models of Posttraumatic Seizures and Epilepsy
Closed-Head TBI Model of Multiple Morbidity
Outcome Measures in Brain Injury Models
Cognitive Evaluation Using Morris Water Maze in Neurotrauma
Assessment of Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysis in Animal Models of Brain Injury
Detecting Behavioral Deficits Post Traumatic Brain Injury in Rats
Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma
Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure Myography
Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph
Magnetic Resonance Imaging in Experimental Traumatic Brain Injury
A Simplified Workflow for Protein Quantitation of Rat Brain Tissues Using Label-Free Proteomics and Spectral Counting
Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury
Postnatal Neural Stem Cells in Treating Traumatic Brain Injury
A Novel Biopsy Method for Isolating Neural Stem Cells from the Subventricular Zone of the Adult Rat Brain for Autologous Transplantation in CNS Injuries
Future Directions in Neurotrauma Research
Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice