Schmidt-Traub H. Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents

Wiley-VCH, 2005. — 486 p.During the last decade, intensive research and development have considerably improved the acceptance and industrial applicability of chromatographic processes. An important key for this success has been the cooperation of different disciplines, in particular chemists and engineers, who have quite different views on preparative chromatography. A chemist, for instance, would say: „Look at the chromatogram, it tells you how to separate a mixture if you also know the chemical structure of the components.“ The engineer may say: „First of all I have to model the process to
understand how it works. I can then explain and optimize the separation of a mixture of components that always have the names A, B and C“. Faced with these statements an experienced chromatographer recommended that „We should drink mobile phase at night and discuss how to proceed“. Having followed this advice we, a group of chemists and engineers, decided to write this book.Fundamentals and General Terminology
Columns, Packings and Stationary Phases
Selection of Chromatographic Systems
Process Concepts
Modeling and Determination of Model Parameters
Model Based Design and Optimization
Chromatographic Reactors
Advanced Control of Simulated Moving Bed Processes