Rueff J., Rodrigues A.S. (Ed.) Cancer Drug Resistance. Overviews and Methods

Humana Press, 2016 — 314p. — (Methods in Molecular Biology 1395) — ISBN: 978-1-4939-3347-1 (eBook), 978-1-4939-3345-7 (Hardcover).This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint
Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance
In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs
In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin
Uptake and Permeability Studies to Delineate the Role of Efflux Transporters
Dynamics of Expression of Drug Transporters: Methods for Appraisal
Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter
Resistance to Targeted Therapies in Breast Cancer
MicroRNAs and Cancer Drug Resistance
The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis
Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues
The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance
Cancer Exosomes as Mediators of Drug Resistance
Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors
Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a Model
Proteomics in the Assessment of the Therapeutic Response of Antineoplastic Drugs: Strategies and Practical Applications
Managing Drug Resistance in Cancer: Role of Cancer Informatics