Weissig Volkmar, Edeas Marvin (Eds). Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function

Humana Press, 2015. — xxiv+
447. — Серия: Methods in Molecular Biology, 1265This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.Содержание:
DQAsomes as the Prototype of Mitochondria-Targeted Pharmaceutical Nanocarriers: Preparation, Characterization, and Use - Volkmar Weissig
Predicting Mitochondrial Targeting by Small Molecule Xenobiotics Within Living Cells Using QSAR Models - Richard W. Horobin
Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide - Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley
Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes - Parul Benein, Mohammed A. Almuteri, Ahmed S. Mehanna, and Gerard G. M. D’Souza
Synthesis and Evaluation of ¹⁸F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging - Dong-Yeon Kim and Jung-Joon Min
Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria - José Teixeira, Pedro Soares, Sofia Benfeito, Michael P. Murphy, Paulo J. Oliveira, and Fernanda Borges
Mitochondriotropic Nanoemulsified Genistein-Loaded Vehicles for Cancer Therapy - Jimmy Pham, Oliver Grundmann, and Tamer Elbayoumi
Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles - Sean Marrache, Rakesh K. Pathak, and Shanta Dhar
Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells - Sean Marrache, Smanla Tundup, Donald A. Harn, and Shanta Dhar
Targeting the Mitochondrial Genome via a Dual Function MITO-Porter: Evaluation of mtDNA Levels and Mitochondrial Function - Yuma Yamada and Hideyoshi Harashima
Mitochondrial, Acidic, and Cytosolic pHs Determination by ³¹P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes - Marcel Culcasi, Sophie Thétiot-Laurent, Ariane Atteia, and Sylvia Pietri
Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research - Mikhail Y. Vyssokikh, Yury N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, and Vladimir P. Skulachev
Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin - Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi
Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents - Katarina Kluckova, Lan-Feng Dong, Martina Bajzikova, Jakub Rohlena, and Jiri Neuzil
The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes - Magdalena Vondrusova, Ayanachew Bezawork-Geleta, Karishma Sachaphibulkij, Jaroslav Truksa, and Jiri Neuzil
Mitochondrial Targeting of Recombinant RNA - Ilya Dovydenko, Anne-Marie Heckel, Yann Tonin, Ali Gowher, Alya Venyaminova, Ivan Tarassov, and Nina Entelis
Mitochondrial Targeting of Catalytic RNAs - Daria Mileshina, Adnan Khan Niazi, Eliza Wyszko, Maciej Szymanski, Romain Val, Clarisse Valentin, Jan Barciszewski, and André Dietrich
Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease - David A. Dunn and Carl A. Pinkert
Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation - Hyang-Min Byun and Timothy M. Barrow
ETS and DEAS Studies of the Reduction of Xenobiotics in Mitochondrial Intermembrane Space - Stanislav A. Pshenichnyuk and Alberto Modelli
Analysis of Mitochondrial Morphology and Function Under Conditions of Mitofusin 2 Deficiency - Juan Pablo Muñoz and Antonio Zorzano
Yeast as a Tool to Study Mitochondrial Retrograde Pathway En Route to Cell Stress Response - Maša Ždralević, Nicoletta Guaragnella, and Sergio Giannattasio
Cell Energy Budget Platform for Assessment of Cell Metabolism - Dmitri B. Papkovsky and Alexander V. Zhdanov
Induced Pluripotent Stem Cells (iPSCs) for Modeling Mitochondrial DNA Disorders - Alessandro Prigione
Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice - Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller
In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans - Reuben L. Smith, Winnok H. De Vos, Richard de Boer, Erik M. M. Manders, and Hans van der Spek
Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin - Amy Bowman and Mark A. Birch-Machin
Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation - Matthias Hecker, Natascha Sommer, and Konstantin Mayer
Atomic Force Microscopy-Based Shape Analysis of Heart Mitochondria - Gi-Ja Lee and Hun-Kuk Park
Enzymatic Assays for Probing Mitochondrial Apoptosis - Zhenyu Wang, Claire Nicolas, Rodolphe Fischmeister, and Catherine Brenner
A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson’s Disease - Daniela M. Arduíno, A. Raquel Esteves, Russell H. Swerdlow, and Sandra M. Cardoso
Analysis of Mitochondrial Network by Imaging: Proof of Technique in Schizophrenia - Dorit Ben-Shachar, Edith Suss-Toby, and Odile Robicsek